ARFIP2, CDC42, CHUK, ELK1, FOS, GRB2, HRAS, IKBKB, IKBKE, IKBKG, JAK1, JAK2, JAK3, JUN, KRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP3K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MRAS, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PIK3...C2A, PIK3C2B, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3R1, PIK3R2, PLA2G1B, PLA2G2A, PLCG1, PLCG2, PTGS2, PTPN11, RAC1, RAF1, RASA1, REL, RELA, RELB, RHOA, RRAS, RRAS2, SHC1, SHC2, SHC3, SLC9A1, SLC9A2, SLC9A3, SLC9A4, SLC9A6, SLC9A7, SOS1, SOS2, SRC, SRF, STAT1, STAT2, STAT3, STAT4, STAT5B, STAT6, TIAM1, VAV1, VAV2, WASL
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PDGF (Platelet-Derived Growth Factor) is a member of a large family of growth factors, which includes VEGF (Vascular Endothelial Growth Factor), PlGF (Placental Growth Factor), and CTGF (Connective Tissue Growth Factor), a PDGF-like factor secreted by hum ...an vascular endothelial cells and fibroblasts. PDGF is a dimeric peptide of homologous A and B-polypeptide chains, which are assembled as homodimers (PDGFAA and PDGFBB) or heterodimer (PDGFAB). PDGF regulates its biological functions on target cells through its binding to specific structurally related high-affinity receptors on cell surface, denoted Alpha and Beta. The PDGFR-Alpha binds PDGFAA and PDGFBB, whereas the PDGFR-Beta binds PDGFBB only. PDGFR (PDGF Receptors) are not uniformly distributed in the cell membrane, but rather concentrated in caveolae, distinct membrane invaginations which are involved in endocytosis. Upon ligand binding, the PDGFR dimerizes and autophosphorylates on a number of tyrosine residues. Tyrosine phosphorylated sites are used by PDGFR as anchor sites for various SH2 domain-containing proteins. Ligand binding induces internalization of the ligand-PDGFR complex into the endosomes. Upon fusion of the endosomes with lysosomes the PDGFR complex is degraded. In addition to degradation in lysosomes, PDGFRs also undergo cytoplasmic degradation in proteasomes after ubiquitination. Cell migration is triggered by a gradient of chemotactic factors, including PDGF (Platelet-Derived Growth Factor) and its receptors.
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