T cell function is dependent upon and controlled by a variety of inducible structures that may have stimulatory (ICOS, OX40, and 4-1BB) or inhibitory (cytotoxic T-lymphocyte antigen [CTLA-4/CD152], B and T lymphocyte attenuator [BTLA/CD272]) potential. Some of these receptors act as either immune inhibitors or activators depending upon the stimulatory environment.

Most co-stimulatory and inhibitory molecules are organized into two families based upon their sequence similarities. The Ig superfamily includes the co-stimulatory receptor, CD28 and inducible costimulator (ICOS/CD278), and the inhibitory receptors, (CD152), programmed cell death-1 (PD-1/CD279), CD272 and CD160. The tumor necrosis factor (TNF) superfamily includes the co-stimulatory receptors CD40, CD134 (OX40), and herpes virus entry mediator (CD270 HVEM).


Co-stimulation - Receptor - Ligand Quick Guide

Receptor Human FG Ab
Cat. No.
Mouse FG Ab
Cat. No.
Family Expression Signal Ligand Human FG Ab
Cat. No.
Mouse FG Ab
Cat. No.
Ligand Expression
CD2 16-0029 16-0021 IgSF T, B and NK cells + CD58 (LFA-3) - - - - Hematopoietic,
non-hematopoietic cells
CD4 16-0049 16-0041 IgSF T subset and Macro/ Mono + and - MHC class II (I-A/I-E) - - 16-5321 B, Marco/Mono, DC and human T cells
CD28 16-0289 16-0281 IgSF T cells + CD80 (B7-1)
CD86 (B7-2)
16-0809
16-0869
16-0801
16-0861
16-0862
B, Macro/Mono, DC and activated T cells
CD152 (CTLA-4) 16-1529 16-1521 IgSF B and activated T cells - CD80 (B7-1) CD86 (B7-2) 16-0809
16-0869
16-0801
16-0861
16-0862
B, Marco/Mono, DC and activated T cells
CD160 1609
(clone BY55)
16-1601 IgSF T, NK and NKT cells - CD270 (HVEM)
MHC class I (H-2Db)
5969 (clone HVEM-122)
9958 (clone A4)
5962 (clone
LH1) 16-5957
16-5999
T, B, DC, Macro/Mono and NK cells
CD223 (Lag-3)   16-2231 IgSF Activated T, B and NK cells - MHC class II (I-A/I-E) - - 16-5321 B, Marco/Mono, DC and human T cells
CD244 (2B4) 16-5838
16-2449
244F4 IgSF NK, T subset, Basophils and Macro/Mono + and - CD48 16-0489 16-0481 Most leukocytes
CD272 (BTLA) 16-5979 16-5950 IgSF Activated T, Th1, B and DC cells - CD270 (HVEM) 5969 (clone HVEM-122) 5962
(clone LH1)
T, B, DC, Macro/Mono and NK cells
CD274
(B7-H1/PD-L1)
- - - - IgSF B, Marco/Mono, DC, T and NK cells - CD80 (B7-1) 16-0809 16-0801 B, Macro/Mono, DC and activated T cells
CD278 (ICOS) 16-9948 16-9942
16-9949
IgSF Activated T, Th2 and NKT cells + CD275
(B7-H2, ICOS-L)
16-5889 16-5985 B, Marco/Mono, DC and endothelial cells
CD279 (PD-1) 16-9989 16-5982
16-9985
IgSF Activated T, activated B, DC and Macro/Mono - CD274 (B7-H1, PD-L1) CD273 (B7-DC, PD-L2) 16-5983
16-5888
16-9982
16-5986”
B, Marco/Mono, DC, T and NK, Marco/Mono and DC cells
TIM3 3109 (clone F38-2E2) 16-5871 IgSF T, B, DC, Macro/Mono and NK cells - Galectin 9 - - - - T, Treg and others
CD27 16-0271
16-0272
16-0271
16-0272
TNFRSF T, B subset, NK subset and HSC + CD70 - - 16-0701 Activated T, B and DC cells
CD30 0309 (clone Ber-H2) 16-0301 TNFRSF Activated T, B and NK cells + CD153 (CD30L) - - 16-1531 B and activated T cells
CD134 (OX40) 1347 (clone ACT-35) 16-1341 TNFRSF Activated T, B, DC and Marco/Monos + (- for Treg) CD252 (OX40
Ligand)
- - 16-5905 Activated T, Treg, NKT, NK and neutrophils
CD137 (4-1BB) 1379 (clone 4B4) 16-1371 TNFRSF Activated T, Macro/ Mono, DC and NK cells + CD137 Ligand (4-1BBL) - - 16-5901 B, DC and Macro/Mono
CD154 (CD40L) 16-1548 16-1541 TNFRSF Activated T, B and platelets cells + CD40 16-0409 16-0402 B, DC, Macro/Mono and endothelial cells
CD270 (HVEM) 5969
(clone HVEM-122)
5962
(clone LH1)
TNFRSF T, B, DC, Macro/Mono, and NK cells + CD258 (LIGHT) CD272 (BTLA)
CD160
2589
(clone 7-3)
16-5979
1609
(clone BY55)
- -
16-5950
16-1601
Activated T and B, DC, Marco/Monos and
NK cells
CD357 (GITR) 5875 (clone AITR) 16-5874 TNFRSF Activated T, Treg and NK cells + GITR Ligand - - 5854 (clone
YGL 386)
B, DC, Macro/Mono and endothelial cells
Lymphotoxon β
Receptor
- - 16-5671 TNFRSF DC, Macro/Mono and stromal cells + CD258 (LIGHT)
LTαβ
2589
(clone 7-3) - -
- -
- -
Activated T and B, DC, Marco/Monos and
NK cells