Genomics and proteomics search results

JAK3 Recombinant Human Protein

Janus kinase 3 (JAK3) phosphorylates members of the STAT (signal transduction and activators of transcription) family. JAK3 is predominantly expressed in immune cells and transduces a signal in response to activation of interleukin receptors. ...

Specifications

Form
Frozen
Species
Human
Gene Aliases
JAK3, LJAK, JAKL
Protein Form
Catalytic
Accession Number
NP_000206
Molecular Weight
67.4 kDa
Research Category
Drug Development
Validated Application
Kinase Assay
Protein Tag or Fusion
GST Tag
Expression
Baculovirus
Kinase Family
JAK Kinase Family
Kinase Group
Tyrosine Kinases
Shipping Condition
Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

PV4080
625cf079f02d0b2f16fff1b6cf37596a_CmgtBuyProduct

Novex™ JAK3 Antibody (515R6) (Novex™)

JAK 3 (also designated L JAK) is a member of the Janus family of protein tyrosine kinases along with JAK 1, JAK 2, or Tyk 2. Subsequent to activation, these kinases function to activate various members of the Stat family of transcription factors by phosphorylation on critical tyr ...

Specifications

Reactivity
Human
Validated Application
Western Blot
Host Species
Mouse
Clonality
Monoclonal
Clone ID
515R6
Target Gene
JAK3
Gene ID
3718
Label or Dye
Unconjugated
Purification
Affinity Purified
Research Category
Signal Transduction
Shipping Condition
Approved for shipment on Wet or Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

AHO1572
6cac7a3b2e2d79dcd2847a01bee34e1b_CmgtBuyProduct

Pierce™ JAK3 Antibody (5H2) (Thermo Scientific™)

MA5-15561 targets JAK3 in FACS, IF, and WB applications and shows reactivity with Human and mouse samples. ...

Specifications

Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.
MA515561
204bd650a5399830fb29505055c9d9f1_CmgtBuyProduct

Novex™ Phospho-JAK2 pTyr1007 / pTyr1008 Antibody (Novex™)

Janus Activating Kinase 2 (JAK2) is one of a number of related tyrosine kinases involved in cytoplasmic signal transduction. In response to a varitety of cytokine or related factors (e.g., interferon, interleukins), JAKs are activated via phosphorylation at 2 adjacent tyrosine re ...

Specifications

Reactivity
Human
Rat
Mouse
Validated Application
Western Blot
Host Species
Rabbit
SubClass (Isotype)
IgG
Clonality
Polyclonal
Target Gene
JAK2 [pYpY1007/1008]
Gene ID
3717
Label or Dye
Unconjugated
Target Modification State
Phospho
Research Category
Signal Transduction
Shipping Condition
Approved for shipment on Wet or Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

44426G
49656d274f5d2650e75c16eda7b71b5f_CmgtBuyProduct

LanthaScreen® Tb-PY20 Antibody Kit

A general reagent to monitor tyrosine kinase activity, the pY20 antibody binds to phosphorylated tyrosines within a peptide or physiological protein substrate. ...

Specifications

Format
384-well plate
Readout
End Point
Technique
TR-FRET
Label or Dye
Tb (Terbium)
FITC (Fluorescein)
Target Enzyme
Tyrosine Kinases
Validated Kinases
ABL1, ABL2, AXL, BLK, BMX, BTK, CSF1R, CSK, DDR2, EGFR, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, ERBB2, ERBB4, FER, FGFR1, FGFR2, FGFR3, FGFR4, FGR, FLT1, FLT3, FLT4, FRK, FYN, HCK, IGF1R, INSR, KDR, KIT, LCK, LTK, LYNA, LYNB, MATK, MERTK, MET, MST1R, MUSK, NTRK1, NTRK2, NTRK3, PDGFRA, PDGFRB, PTK2, PTK2B, PTK6, RET, ROS1, SRC, SRCN1, SRMS, SYK, TEC, TEK, TNK2, TTK, TYRO3, YES1, ZAP70
Antibody Molecular Weight
150000 Da
Excitation⁄Emission (nm)
340⁄490, 520
Shipping Condition
Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

PV3553
e83e711838c5a3c1af253a2b725376aa_CmgtBuyProduct

Fluorescein-Poly GAT

A general fluorescein peptide substrate consisting of a polymer of glutamate, alanine, and tyrosine that is used to monitor tyrosine kinase activity. ...

Specifications

Substrate
Fluorescein-Poly GAT
Label or Dye
FITC (Fluorescein)
Target Enzyme
Tyrosine Kinases
Substrate Type
Kinase Substrate
Detection Method
Fluorescent
Validated Kinases
ABL1, ABL2, AXL, BLK, BMX, BTK, CSF1R, CSK, DDR2, EGFR, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, ERBB2, ERBB4, FER, FGFR1, FGFR2, FGFR3, FGFR4, FGR, FLT1, FLT3, FLT4, FRK, FYN, HCK, IGF1R, INSR, KDR, KIT, LCK, LTK, LYNA, LYNB, MATK, MERTK, MET, MST1R, MUSK, NTRK1, NTRK2, NTRK3, PDGFRA, PDGFRB, PTK2, PTK2B, PTK6, RET, ROS1, SRC, SRCN1, SRMS, SYK, TEC, TEK, TNK2, TTK, TYRO3, YES1, ZAP70
Amino Acid Sequence
Fluorescein- Poly Glu:Ala:Tyr (6:3:1)
Substrate Properties
Peptide-Based Substrate
Shipping Condition
Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

PV3611
2f7ff130727e71fa4314b503cfd9db47_CmgtBuyProduct

LanthaScreen® Tb-pSTAT3 [pTyr705] Antibody Kit

A part of the JAK/STAT Pathway, STAT3 (Signal Transducer and Activator of Transcription 3) is phosphorylated at Tyr705 by the Janus family of tyrosine kinases. ...

Specifications

Format
384-well plate
Readout
End Point
Technique
TR-FRET
Reactivity
Human
Label or Dye
Tb (Terbium)
GFP (EmGFP)
Target Enzyme
Tyrosine Kinases
Validated Kinases
JAK1, JAK2, JAK3, TYK2
Antibody Molecular Weight
150000 Da
Excitation⁄Emission (nm)
340⁄490, 520
Shipping Condition
Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

PV4847
487f006f6ea080601e3a86699f45b3fa_CmgtBuyProduct

LanthaScreen® Tb-anti-pSTAT1 [pTyr701] Antibody Kit

A part of the JAK/STAT Pathway, STAT1 (Signal Transducer and Activator of Transcription 1) is phosphorylated at Tyr701 by the Janus family of tyrosine kinases. ...

Specifications

Format
384-well plate
Readout
End Point
Technique
TR-FRET
Reactivity
Human
Label or Dye
Tb (Terbium)
GFP (EmGFP)
Target Enzyme
Tyrosine Kinases
Validated Kinases
JAK1, JAK2, JAK3, TYK2
Antibody Molecular Weight
150000 Da
Excitation⁄Emission (nm)
340⁄490, 520
Shipping Condition
Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

PV4844
2a334e63a4ff9ead83fb18b5248485a5_CmgtBuyProduct

Pierce™ Phospho-JAK3 pTyr785 Antibody (Thermo Scientific™)

JAK 3 (also designated L JAK) is a member of the Janus family of protein tyrosine kinases along with JAK 1, JAK 2, or Tyk 2. Subsequent to activation, these kinases function to activate various members of the Stat family of transcription factors by phosphorylation on critical tyr ...

Specifications

Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.
f35fde2978fb9bf5145541b00f939f74_CmgtBuyProduct

Novex™ JAK2 Antibody (691R5) (Novex™)

Janus Activating Kinase 2 (JAK2) is one of a number of related tyrosine kinases involved in cytoplasmic signal transduction. In response to a varitety of cytokine or related factors (e.g., interferon, interleukins), JAKs are activated via phosphorylation at 2 adjacent tyrosine re ...

Specifications

Reactivity
Human
Mouse
Rat
Validated Application
Western Blot
Host Species
Mouse
Clonality
Monoclonal
Clone ID
691R5
Target Gene
JAK2
Gene ID
16452, 24514, 3717
Label or Dye
Unconjugated
Research Category
Signal Transduction
Shipping Condition
Approved for shipment on Wet or Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

AHO1352
6e1a421bbb44214d253af264e6b257b9_CmgtBuyProduct

Novex™ JAK2 Antibody (Novex™)

Janus Activating Kinase 2 (JAK2) is one of a number of related tyrosine kinases involved in cytoplasmic signal transduction. In response to a varitety of cytokine or related factors (e.g., interferon, interleukins), JAKs are activated via phosphorylation at 2 adjacent tyrosine re ...

Specifications

Reactivity
Human
Mouse
Validated Application
Western Blot
Host Species
Rabbit
SubClass (Isotype)
IgG
Clonality
Polyclonal
Target Gene
JAK2
Gene ID
3717
Label or Dye
Unconjugated
Research Category
Signal Transduction
Shipping Condition
Approved for shipment on Wet or Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

44406G
d62f7f973d5c1d43adc48f04059259c6_CmgtBuyProduct

CellSensor® STAT6-bla RA-1 Cell Line

The CellSensor® STAT6-bla RA-1 Cell Line contains a beta-lactamase reporter gene under control of the STAT6 response element stably integrated into Ramos-1 (RA-1) cells. This cell line is a clonal population isolated by flow cytometry in response to interleukin-4 (IL-4). This ce ...

Specifications

System
CellSensor™
Cell State
Dividing Cells
Druggable Target
Signaling Pathway
Cytokines
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

K1646
262dce2016e04a8461d19f8c88752daa_CmgtBuyProduct

Phospho-JAK3 pTyr785 Antibody (Thermo Scientific™)

This antibody is predicted to react with mouse and rat based on sequence homology. ...

Specifications

Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.
PA540264
3f71d8ecbc904cfc499adda00b940c8a_CmgtBuyProduct

Pierce™ STAM Antibody (29C678) (Thermo Scientific™)

Suggested positive control: 293 whole cell lysate, Hela whole cell lysate. ...

Specifications

Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.
MA141179
d8935b467934b557e3250902499b5c03_CmgtBuyProduct