Genomics and proteomics search results

JAK3 Recombinant Human Protein

Janus kinase 3 (JAK3) phosphorylates members of the STAT (signal transduction and activators of transcription) family. JAK3 is predominantly expressed in immune cells and transduces a signal in response to activation of interleukin receptors. ...

Specifications

Gene ID
3718
Species
Human
Target Gene
Janus kinase 3
Gene Aliases
JAK3, LJAK, JAKL
Protein Form
Catalytic
Cytoplasmic
Recombinant
Protein Family
Kinases & Inhibitors
Protein Subtype
Cytoplasmic Tyrosine Kinases
Accession Number
NP_000206
Molecular Weight
67.4 kDa
Research Category
Signal Transduction
System Compatibility
LanthaScreen® Substrate
LanthaScreen® Antibody
Z'-LYTE™
Omnia® Bulk Substrate
Validated Application
Kinase Assay
Protein Length or Portion (a.a.)
aa 781-1124
Protein Tag or Fusion
GST Tag
Expression
Baculovirus
Kinase Family
JAK Kinase Family
Kinase Group
Tyrosine Kinases
Shipping Condition
Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

PV3855
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Novex™ JAK3 Antibody (515R6) (Novex™)

JAK 3 (also designated L JAK) is a member of the Janus family of protein tyrosine kinases along with JAK 1, JAK 2, or Tyk 2. Subsequent to activation, these kinases function to activate various members of the Stat family of transcription factors by phosphorylation on critical tyr ...

Specifications

Reactivity
Human
Validated Application
Western Blot
Host
Mouse
Clonality
Monoclonal
Clone ID
515R6
Target Gene
JAK3
Gene ID
3718
Label or Dye
Unconjugated
Purification
Affinity Purified
Research Category
Signal Transduction
Shipping Condition
Approved for shipment on Wet or Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

AHO1572
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Pierce™ JAK3 Antibody (5H2) (Thermo Scientific™)

MA5-15561 targets JAK3 in FACS, IF, and WB applications and shows reactivity with Human and mouse samples. ...

Specifications

Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.
MA515561
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Novex™ Phospho-Jak3 pTyr980 / pTyr981 Antibody (D44E3)

JAK 3 (also designated L JAK) is a member of the Janus family of protein tyrosine kinases along with JAK 1, JAK 2, or Tyk 2. Subsequent to activation, these kinases function to activate various members of the Stat family of transcription factors by phosphorylation on critical tyr ...

Specifications

Reactivity
Human
Validated Application
Western Blot
Host
Rabbit
SubClass (Isotype)
IgG
Clonality
Monoclonal
Clone ID
D44E3
Antibody Fragment
Whole Antibody
Target Gene
tyrosine-protein kinase JAK3
Gene ID
3718
Gene Symbol
JAK3
Accession Number
P52333
Gene Aliases
JAKL, LJAK, JAK-3, L-JAK, JAK3_HUMAN
Label or Dye
Unlabeled
Target Modification State
Phospho
Form
Liquid
Protein Family
Tyrosine Kinase
Buffer
10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol
Research Category
Immunology
Inflammation
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

A16677
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Novex™ Phospho-JAK2 pTyr1007 / pTyr1008 Antibody (Novex™)

Janus Activating Kinase 2 (JAK2) is one of a number of related tyrosine kinases involved in cytoplasmic signal transduction. In response to a varitety of cytokine or related factors (e.g., interferon, interleukins), JAKs are activated via phosphorylation at 2 adjacent tyrosine re ...

Specifications

Reactivity
Human
Mouse
Rat
Validated Application
Western Blot
Host
Rabbit
SubClass (Isotype)
IgG
Clonality
Polyclonal
Target Gene
JAK2 [pYpY1007/1008]
Gene ID
3717
Label or Dye
Unconjugated
Target Modification State
Phospho
Research Category
Signal Transduction
Shipping Condition
Approved for shipment on Wet or Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

44426G
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LanthaScreen® Tb-PY20 Antibody Kit

A general reagent to monitor tyrosine kinase activity, the pY20 antibody binds to phosphorylated tyrosines within a peptide or physiological protein substrate. ...

Specifications

Format
384-well plate
Readout
End Point
Technique
TR-FRET
Label or Dye
Tb (Terbium)
FITC (Fluorescein)
Target Enzyme
Tyrosine Kinases
Validated Kinases
ABL1, ABL2, AXL, BLK, BMX, BTK, CSF1R, CSK, DDR2, EGFR, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, ERBB2, ERBB4, FER, FGFR1, FGFR2, FGFR3, FGFR4, FGR, FLT1, FLT3, FLT4, FRK, FYN, HCK, IGF1R, INSR, KDR, KIT, LCK, LTK, LYNA, LYNB, MATK, MERTK, MET, MST1R, MUSK, NTRK1, NTRK2, NTRK3, PDGFRA, PDGFRB, PTK2, PTK2B, PTK6, RET, ROS1, SRC, SRCN1, SRMS, SYK, TEC, TEK, TNK2, TTK, TYRO3, YES1, ZAP70
Antibody Molecular Weight
150000 Da
Excitation⁄Emission (nm)
340⁄490, 520
Shipping Condition
Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

PV3552
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LanthaScreen® Tb-pSTAT3 [pTyr705] Antibody Kit

A part of the JAK/STAT Pathway, STAT3 (Signal Transducer and Activator of Transcription 3) is phosphorylated at Tyr705 by the Janus family of tyrosine kinases. ...

Specifications

Format
384-well plate
Readout
End Point
Technique
TR-FRET
Reactivity
Human
Label or Dye
Tb (Terbium)
GFP (EmGFP)
Target Enzyme
Tyrosine Kinases
Validated Kinases
JAK1, JAK2, JAK3, TYK2
Antibody Molecular Weight
150000 Da
Excitation⁄Emission (nm)
340⁄490, 520
Shipping Condition
Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

PV4846
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LanthaScreen® Tb-anti-pSTAT1 [pTyr701] Antibody Kit

A part of the JAK/STAT Pathway, STAT1 (Signal Transducer and Activator of Transcription 1) is phosphorylated at Tyr701 by the Janus family of tyrosine kinases. ...

Specifications

Format
384-well plate
Readout
End Point
Technique
TR-FRET
Reactivity
Human
Label or Dye
Tb (Terbium)
GFP (EmGFP)
Target Enzyme
Tyrosine Kinases
Validated Kinases
JAK1, JAK2, JAK3, TYK2
Antibody Molecular Weight
150000 Da
Excitation⁄Emission (nm)
340⁄490, 520
Shipping Condition
Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

PV4844
2a334e63a4ff9ead83fb18b5248485a5_CmgtBuyProduct

Fluorescein-Poly GAT

A general fluorescein peptide substrate consisting of a polymer of glutamate, alanine, and tyrosine that is used to monitor tyrosine kinase activity. ...

Specifications

Substrate
Fluorescein-Poly GAT
Label or Dye
FITC (Fluorescein)
Target Enzyme
Tyrosine Kinases
Substrate Type
Kinase Substrate
Detection Method
Fluorescent
Validated Kinases
ABL1, ABL2, AXL, BLK, BMX, BTK, CSF1R, CSK, DDR2, EGFR, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, ERBB2, ERBB4, FER, FGFR1, FGFR2, FGFR3, FGFR4, FGR, FLT1, FLT3, FLT4, FRK, FYN, HCK, IGF1R, INSR, KDR, KIT, LCK, LTK, LYNA, LYNB, MATK, MERTK, MET, MST1R, MUSK, NTRK1, NTRK2, NTRK3, PDGFRA, PDGFRB, PTK2, PTK2B, PTK6, RET, ROS1, SRC, SRCN1, SRMS, SYK, TEC, TEK, TNK2, TTK, TYRO3, YES1, ZAP70
Amino Acid Sequence
Fluorescein- Poly Glu:Ala:Tyr (6:3:1)
Substrate Properties
Peptide-Based Substrate
Shipping Condition
Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

PV3611
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Pierce™ Phospho-JAK3 pTyr785 Antibody (Thermo Scientific™)

JAK 3 (also designated L JAK) is a member of the Janus family of protein tyrosine kinases along with JAK 1, JAK 2, or Tyk 2. Subsequent to activation, these kinases function to activate various members of the Stat family of transcription factors by phosphorylation on critical tyr ...

Specifications

Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.
f35fde2978fb9bf5145541b00f939f74_CmgtBuyProduct

Omnia® Y Peptide 7 Kit

The Omnia® kinase assay utilizes peptide substrates incorporating the proprietary SOX moiety to measure phosphorylation in an antibody-free format. This enables the user to conduct real-time kinetic kinase assays by a single step addition of substrate to kinase. The Y7 Omnia® p ...

Specifications

Form
Frozen
Color
Green
Gene ID
1436, 1956, 2260, 2321, 2322, 2324, 2444, 25, 3717, 3718, 3791, 5979, 6850
Readout
Kinetic
Technique
Fluorescence Intensity
Assay Type
Tyrosine Kinase Assay
References
Nature Methods Vol 2 pps 277-283 (2005) and JACS Vol 125 pps 14248 - 14249 (2003)
Label or Dye
Sox Chelation-Enhanced Fluorophore
Target Enzyme
Tyrosine Kinases
Substrate Type
Kinase Substrate
Detection Method
Fluorescent
Molecular Weight
1455.1 Da
Validated Kinases
JAK3, SYK
Amino Acid Sequence
Ac-EEEEYIQdP(Sox)G-NH2
Substrate Properties
Peptide-Based Substrate
For use with (Equipment)
Microplate Reader
Excitation⁄Emission (nm)
360⁄485
Shipping Condition
Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

KNZ3071
0abf7119bb9bb8cd91940352a6f52046_CmgtBuyProduct

Novex™ JAK2 Antibody (691R5) (Novex™)

Janus Activating Kinase 2 (JAK2) is one of a number of related tyrosine kinases involved in cytoplasmic signal transduction. In response to a varitety of cytokine or related factors (e.g., interferon, interleukins), JAKs are activated via phosphorylation at 2 adjacent tyrosine re ...

Specifications

Reactivity
Human
Mouse
Rat
Validated Application
Western Blot
Host
Mouse
Clonality
Monoclonal
Clone ID
691R5
Target Gene
JAK2
Gene ID
16452, 24514, 3717
Label or Dye
Unconjugated
Research Category
Signal Transduction
Shipping Condition
Approved for shipment on Wet or Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

AHO1352
6e1a421bbb44214d253af264e6b257b9_CmgtBuyProduct

Novex™ JAK2 Antibody (Novex™)

Janus Activating Kinase 2 (JAK2) is one of a number of related tyrosine kinases involved in cytoplasmic signal transduction. In response to a varitety of cytokine or related factors (e.g., interferon, interleukins), JAKs are activated via phosphorylation at 2 adjacent tyrosine re ...

Specifications

Reactivity
Human
Mouse
Validated Application
Western Blot
Host
Rabbit
SubClass (Isotype)
IgG
Clonality
Polyclonal
Target Gene
JAK2
Gene ID
3717
Label or Dye
Unconjugated
Research Category
Signal Transduction
Shipping Condition
Approved for shipment on Wet or Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

44406G
d62f7f973d5c1d43adc48f04059259c6_CmgtBuyProduct

CellSensor® STAT6-bla RA-1 Cell Line

The CellSensor® STAT6-bla RA-1 Cell Line contains a beta-lactamase reporter gene under control of the STAT6 response element stably integrated into Ramos-1 (RA-1) cells. This cell line is a clonal population isolated by flow cytometry in response to interleukin-4 (IL-4). This ce ...

Specifications

System
CellSensor™
Cell State
Dividing Cells
Druggable Target
Signaling Pathway
Cytokines
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

K1646
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