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The Ion GeneStudio S5 Series is flexibly designed to enable a broad range of targeted NGS applications with industry-leading speed and scalability. Select from five different sequencing chips to sequence a throughput range from 2M to 130M reads per run. Simply choose the chip size and the instrument that matches your throughput and application needs.

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Meet the Ion GeneStudio S5 system

Which Ion GeneStudio S5 System is right for you?

Ion GeneStudio S5 System

Ion S5 and S5 XL NGS Sequencing Systems

Inquire
Get started with targeted NGS

Ion GeneStudio S5 Plus System

Ion S5 and S5 XL NGS Sequencing Systems

Discover
Choose flexibility to support small and large projects

Ion GeneStudio S5 Prime System

S5 XL NGS Sequencing Systems

Decide
Save time with greater throughput

Ion chip compatibility

Ion 510 Chip
Ion 520 Chip
Ion 530 Chip
Ion 540 Chip
Ion 510 Chip
Ion 520 Chip
Ion 530 Chip
Ion 540 Chip
Ion 550 Chip
Ion 510 Chip
Ion 520 Chip
Ion 530 Chip
Ion 540 Chip
Ion 550 Chip

Maximum throughput/day (chip type)

15 Gb (1 Ion 540 Chip)

30 Gb (2 Ion 540 chips)

50 Gb (2 Ion 550 chips)

Speed

19 hrs (Ion 540 Chip)

10 hrs (Ion 540 Chip)
11.5 hrs (Ion 550 Chip)

6.5 hrs (Ion 540 Chip)
8.5 hrs (Ion 550 Chip)


Learn about the simple workflow of the Ion GeneStudio S5 Series


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DNA to data with less than 45 minutes of hands-on time

With simple cartridge-loaded reagents and a straightforward user interface, the Ion GeneStudio S5 Series makes NGS fast and easy—ideal for any cancer or inherited disease research lab.

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“The Ion Chef and S5 workflow is as simple as using a coffee pod machine but with espresso quality coffee.”

--Dr. Lesley Cheng, Postdoctoral researcher, Department of Biochemistry and Genetics, La Trobe University, Australia


Ion GeneStudio S5 Series targeted sequencing workflow

Total hands-on time: less than 45 minutes

Ion Gene Studio Workflow

Step 1: Prepare

Library and template preparation with Ion AmpliSeq libraries and the Ion Chef System

Total hands-on time: 30 minutes

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Paired with Ion Torrent next-generation sequencing platforms (Ion PGM, Ion PGM Dx—assay development mode, Ion Proton, and Ion GeneStudio S5 Series), the Ion Chef System automates Ion AmpliSeq library preparation, template generation, and chip loading with push-button simplicity—enabling a DNA-to-data targeted sequencing workflow with as little as 45 minutes of hands-on time.

Watch the video to learn the quick steps involved in setting up the Ion Chef System for automated library preparation and template preparation. The final loaded chips can then be directly placed on the Ion S5 System for sequencing.

Step 2: Sequence

Sequencing with the Ion GeneStudio
S5 Series

Total hands-on time: <15 minutes

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In this video, you will see how simple the Ion GeneStudio S5 Series is to set up. First, the video walks through initialization, a quick 30-minute process that gets the system ready for sequencing. Then, you just simply need to swap out the old chip used for initialization with the chip containing your samples, loaded during the Ion Chef System run.

And as far as speed is concerned, sequencing on the Ion GeneStudio S5 Series is fast—allowing you to complete a run in as little as two hours, thanks to the semiconductor sequencing technology.

Step 3: Analyze

Data analysis with Ion Reporter Software

Test drive Ion Reporter Software

Analysis of next-generation sequencing data is always perceived as being difficult and complicated. Ion Reporter Software provides an optimized suite of simple tools that streamline the Ion GeneStudio S5 Series data analysis steps, so you can focus on finding relevant variants for your research. From human variant detection (SNPs, indels, gene fusions, tumor-normal analysis, trio analysis, and more) to assessing microbial diversity, NGS data analysis has become easy with Ion Reporter Software.

Step 1: Prepare

Library and template preparation with Ion AmpliSeq libraries and the Ion Chef System

Total hands-on time: 30 minutes

Get a quote

Paired with Ion Torrent next-generation sequencing platforms (Ion PGM, Ion PGM Dx—assay development mode, Ion Proton, and Ion GeneStudio S5 Series), the Ion Chef System automates Ion AmpliSeq library preparation, template generation, and chip loading with push-button simplicity—enabling a DNA-to-data targeted sequencing workflow with as little as 45 minutes of hands-on time.

Watch the video to learn the quick steps involved in setting up the Ion Chef System for automated library preparation and template preparation. The final loaded chips can then be directly placed on the Ion S5 System for sequencing.

Step 2: Sequence

Sequencing with the Ion GeneStudio
S5 Series

Total hands-on time: <15 minutes

Get a quote

In this video, you will see how simple the Ion GeneStudio S5 Series is to set up. First, the video walks through initialization, a quick 30-minute process that gets the system ready for sequencing. Then, you just simply need to swap out the old chip used for initialization with the chip containing your samples, loaded during the Ion Chef System run.

And as far as speed is concerned, sequencing on the Ion GeneStudio S5 Series is fast—allowing you to complete a run in as little as two hours, thanks to the semiconductor sequencing technology.

Step 3: Analyze

Data analysis with Ion Reporter Software

Test drive Ion Reporter Software

Analysis of next-generation sequencing data is always perceived as being difficult and complicated. Ion Reporter Software provides an optimized suite of simple tools that streamline the Ion GeneStudio S5 Series data analysis steps, so you can focus on finding relevant variants for your research. From human variant detection (SNPs, indels, gene fusions, tumor-normal analysis, trio analysis, and more) to assessing microbial diversity, NGS data analysis has become easy with Ion Reporter Software.

Single sequencer.  Multiple applications.

The Ion GeneStudio S5 Series supports five different chip types, enabling different throughput and application needs. This flexibility also means you don't have to batch samples to achieve the optimum cost efficiency. Just choose the chip type that matches your specific throughput or application needs.

Learn more about NGS applications and see available app notes ›

Researchers-S5-Geoff-Loading-Chip-375

Simple protocol. Same day results.

Get results in as little as 24 hours (with 2.5-4 hour sequencer run times) using the Ion GeneStudio S5 Prime System—the fastest turnaround of any benchtop sequencer.  Enjoy the simple protocol with load-and-go reagents and a straightforward user interface, allowing sequencer setup in less than 15 minutes of hands-on time. Add an Ion Chef System to your lab to benefit from automated library and template preparation.

Learn how semiconductor sequencing works ›

S5_Prime

Minimize sample input. Maximize flexibility.

Ion AmpliSeq technology enables successful library preparation from challenging sample types such as formalin-fixed, paraffin-embedded (FFPE) tissue, retrospective samples from fine needle aspirates, and cell-free DNA (cfDNA) extracted from blood, using as little as 1 ng of input DNA or RNA to support multiple applications.

Learn more about Ion AmpliSeq technology ›

Go from DNA to variants in a few clicks

Torrent Suite Software and Ion Reporter Software make it easy for you to get started with your sequencing runs.  Plan, monitor, track, and analyze your runs using Torrent Suite Software (pre-installed on the Torrent Server).  Integrate, annotate, and interpret variants using Ion Reporter Software (cloud or local options available based on your needs). 

Learn more about NGS data analysis ›

Get expert answers. And peace of mind.

A global network of over 1,300 service and support personnel are dedicated to helping you maximize data integrity and instrument investment.  Through technical support, bioinformatics services, data storage, IT services, qualification services, application training, and optional extended warranty contracts, we can help provide peace of mind and increase laboratory productivity.

Speed and flexibility improve lab competitiveness

“In my institute, many customers outsource for exome and whole genome studies.  They come to me for speed, and flexibility for different gene panels, tailored to disease areas of interest.  This is the most elegant workflow on the market today, and I can now offer a range of applications and deliver the data in the fastest turnaround time in the market, at costs that are competitive.” 

—Morten Dunoe, Lab Manager, Molecular Genetic Laboratory, Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Denmark

 

See what you can do—delve into application notes

Cancer Genomics Transcriptomics Research

Cancer genomics and transcriptomics research

Low Frequency Mutations Cell Free DNA

Low-frequency mutations from cell-free DNA

Reproductive Genomics Inherited Disease Research

Reproductive genomics and inherited disease research

Rapid Sequencing Microorganisms

Rapid sequencing of microorganisms

Resources