Ion Chromatography Mass Spectrometry (IC-MS)

Increase the power of IC with MS detection

Utilize mass detection when you need to ensure analytical confidence and dramatically improve the detection capability of your Thermo Scientific Dionex Integrion or ICS-5000+ HPIC system. Ion chromatography with mass spectrometry (IC-MS) maximizes the ability to detect and quantify unexpected co-elutions of components and to confirm trace components.

Popular IC-MS products
IC-MS systems

Coupling MS with your IC can give you more information from every sample:

  • Higher sensitivity
  • Accurate quantitation
  • Peak confirmation and evaluation of chromatographic peak purity
  • Increased efficiency
Single Quadrupole IC-MS

Easily master MS for your IC applications.

An easy-to-use, high-performance benchtop system, the Thermo Scientific ISQ EC MS system offers more information about your sample than ever before with increased sensitivity and quantitative accuracy.

Triple Quadrupole IC-MS

Need sensitive, fast, and robust quantitation of a variety of molecule types? For complex samples, the high sensitivity and selectivity of MS/MS using selected reaction monitoring (SRM) provides the most precise and accurate quantitation using IC-MS.

Exceed the most stringent analytical requirements for quantitative performance. Get attogram-level sensitivity in a system that’s exceptionally robust and easy to use.

The TSQ Quantis MS helps you achieve unprecedented experimental sensitivity for all molecular species in complex matrices without sacrificing robustness.

Orbitrap IC-MS

Thermo Scientific Orbitrap mass spectrometers generate high-resolution and accurate-mass data, thereby enhancing sensitivity in trace analyte detection, characterization, and quantitation. That's why they are used in research applications—in particular, life science applications such as metabolomics.

Get a superior combination of scan speed, high resolution, mass accuracy, spectral quality and sensitivity for untargeted or targeted screening and a broad range of qualitative and quantitative applications in environmental, food safety and metabolomics.

Use this system for IC-MS in life science metabolomics research to analyze the most challenging low-abundance, high-complexity samples, to identify more compounds faster, quantify more accurately, and to elucidate structures more thoroughly.

Which mass spectrometer do I choose?

Mass Spectrometer Analyzer Mode of Operation MS MS/MS Sensitivity Peak Confirmation Structural Elucidation
ISQ EC MS Quadrupole Single ion monitoring (SIM)
TSQ Altis MS Triple Quadrupole Selected reaction monitoring (SRM)
TSQ Quantis MS Triple Quadrupole Selected reaction monitoring (SRM)
Q Exactive MS Orbitrap mass analyzer High Resolution Accurate Mass (HRAM)
Orbitrap Fusion MS Orbitrap mass analyzer High Resolution Accurate Mass (HRAM)
  = Not applicable   = Poor   = Good   = Better   = Best

IC-MS basics and benefits videos


Webinar: Get More From Your Ion Analyses Using Mass Spectrometric Detection
Webinar: Get More From Your Ion Analyses Using Mass Spectrometric Detection

If your lab faces ion analysis challenges around sensitivity, selectivity, or peak confirmation, you may want to consider coupling your ion chromatography (IC) analyses with mass spectrometric detection (IC-MS).

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