Kinases for disease research

No matter your therapeutic area of research, Thermo Fisher Scientific provides a wide array of products and profiling services to support your discovery and development needs. From kinases, GPCR, nuclear receptors, ion channels and more, we have a long history of providing high-quality products, with the service and support you expect from a market leader in drug development.  

To help get you started on your journey to developing the next promising drug candidate, here are a handful of the most-referenced Invitrogen kinase products for each therapeutic area. Alternatively, you can go straight to our selection and ordering tool.

Don’t see the kinase products or services you are looking for? Let our team of experts meet with you to find the best solution for your drug discovery and development needs at thermofisher.com/askdiscovery.

On this page:

Cancer research kinases

Cancer research

Cancer represents the largest research area currently being studied in any field of science and as such the discovery and development of molecule inhibitors that target cellular signaling responsible for tumor development, angiogenesis, cancer progression and metastasis, is inherent in anticancer prevention and treatments.

Thermo Fisher Scientific offers over 490 purified kinase proteins for therapeutic research and over 350 kinases that have been cited for cancer research in over 140,000 published papers.

To better understand the overall Thermo Fisher Scientific aim of pursuing a life without cancer view resources here.

See the full list of mutants and kinases for cancer research
Go to the kinase selection and ordering tool

No records were found matching your criteria

Target Number of citations* Mutants/variants available? Cat. No.
EGFR (ErbB1) 15274 PV3872
MET (CMET) 8799 PV3143
SRC 8011 P3044
MAPK3 (ERK1) 7085   PV3311
ROS1 6245   PV3814
ERBB2 (HER2) 4845   PV3366
BRAF 4187 PV3848
ATM 3774    
ABL1 3525 P3049
BCR 3425    
CDK4 (cyclin D1) 3187 PV4400
PTK2 (FAK) 3000 PV3832
YES1 2955   A15557
CDK2/Cyclin A 2869 PV3267
AKT1 (PKB alpha) 2560   P2999
ALK 2362 PV3867
KIT 2072 P3081
ATR 2040    
RET 1806 PV3819
PDK1 1763   P3001
CHEK1 (CHK1) 1756   P3040
JAK2 1724 PV4210
CDK6/Cyclin D1 1670   PV4401
ABL2 (ARG) 1636   PV3266
ErbB3 1588    
CHEK2 (CHK2) 1557   PV3367
MAPK1 (ERK2) 1530   PV3313
MERTK (cMER) 1329   PV3627
MERTK (cMER) A708S 1322   PV6325
LKB1 1305    
*Reflects the number of published papers discovered from a “common name kinase” + “specific disease area” keyword search in PubMed Central over the period from January 2000 to August 2016.

(Top)

Cancer research kinases

Cardiovascular disease research kinases

Cardiovascular disease research

The leading cause of death worldwide, cardiovascular diseases (CVDs) impacts all corners of the globe from industrialized nations to developing countries. Further complicated by the concurrent growth in common risk factors for cardiovascular disease such as obesity and diabetes, the need to better understand how the disease progresses and the development of novel therapeutic treats is vital. As wide variety of conditions can lead to heart disease including atherosclerosis, heart infections and structural or congenital defects, cardiovascular drug development programs are often quite complex and require multidisciplinary approaches. Novel pharmacological strategies that target specific receptors or proteins involved in CVDs are required for the safe and effective treatment and prevention of cardiovascular disease.

Thermo Fisher Scientific has a wide variety of cardiovascular targets to help advance your research needs.

Thermo Fisher Scientific offers over 490 purified kinase proteins for therapeutic research and over 210 kinases that have been cited for cancer research in over 3,300 published papers.

See the full list of mutants and kinases for cardiovascular research
Go to the kinase selection and ordering tool

No records were found matching your criteria

Target Number of citations* Mutants/variants available? Cat. No.
ROS1 679   PV3814
MAPK3 (ERK1) 280   PV3311
MET (CMET) 255 PV3143
SRC 213 P3044
EGFR (ErbB1) 155 PV3872
YES1 86   A15557
ABL2 (ARG) 61   PV3266
KDR (VEGFR2) 58   PV3660
KIT 56 P3081
AKT1 (PKB alpha) 55   P2999
CSF1R (FMS) 51   PV3249
MAPK8 (JNK1) 49   PV3319
LKB1 46    
PDK1 45   P3001
JAK2 43 PV4210
MAPK1 (ERK2) 43   PV3313
PTK2 (FAK) 43 PV3832
ATM 36    
MERTK (cMER) 34   PV3627
ABL1 32 P3049
AKT2 (PKB beta) 27   PV3184
p70S6K 27   PV6325
ULK1 27   PV6430
ROCK1 26   PV3691
TEK (TIE2) 26 PV3628
EIF2AK2 (PKR) 23   PV4821
ERBB2 (HER2) 23   PV3366
ERN1 22   A30971
IGF1R 21   PV3250
FYN 20 P3042
*Reflects the number of published papers discovered from a “common name kinase” + “specific disease area” keyword search in PubMed Central over the period from January 2000 to August 2016.

(Top)

Cardiovascular disease research kinases

Central nervous system (CNS) disorders research kinases

CNS disorders research

With a significant change in the average age of the world’s population, there has been a concerted shift in research focus into CNS disorders, like Parkinson’s disease, multiple sclerosis and Alzheimer’s disease. Historically, CNS research has focused on targeting extracellular receptors and their respective signaling pathways. Recent advances in antibodies, vaccines, interfering RNA, and other biological therapeutics have yielded promising treatment options for CNS disorders.

Thermo Fisher Scientific offers over 490 purified kinase proteins and paired assays and was the first to commercially offer purified full-length LRRK2 protein—key in Parkinson’s disease research.

We have over 280 kinases cited in over 7,400 published research papers. See the list of kinases for Alzheimer’s disease research, multiple sclerosis research, Parkinson’s disease research, and schizophrenia research below.

For more information regarding Thermo Fisher Scientific’s role in helping researchers unlock the mystery of Parkinson’s disease visit our resources here

See the full list of mutants and kinases for CNS disorders research
Go to the kinase selection and ordering tool

No records were found matching your criteria

Target Number of citations* Mutants/variants available? Cat. No.
ROS1 123   PV3814
CDK5/p25 109   PV4676
MAPK3 (ERK1) 78   PV3311
SRC 69 P3044
MET (CMET) 62 PV3143
FYN 51 P3042
ABL2 (ARG) 38   PV3266
LRRK2 26 PV4873
NTRK1 (TRKA) 24   PV3144
DYRK1A 22   PV3785
MERTK (cMER) 22   PV3627
NTRK2 (TRKB) 21   PV3616
PINK1 21    
CDK1/Cyclin A1 19   PV6280
CDK2/Cyclin A 18 PV3267
EGFR (ErbB1) 18 PV3872
MAPK1 (ERK2) 17   PV3313
MERTK (cMER) A708S 15   PV6325
YES1 15   A15557
ABL1 14 P3049
CDK4 (cyclin D1) 14   PV4400
LKB1 13    
MAPK8 (JNK1) 13   PV3319
MARK2 13   PV3878
EphB2 12   PV3625
PAK1 12   PV3820
GSK3B 11   PV3365
ERN1 10   A30971
EIF2AK2 (PKR) 9   PV4821
ERBB4 (HER4) 9   PV3626
*Reflects the number of published papers discovered from a “common name kinase” + “specific disease area” keyword search in PubMed Central over the period from January 2000 to August 2016.

(Top)

Alzheimer's research kinases

No records were found matching your criteria

Target Number of citations* Mutants/variants available? Cat. No.
ROS1 367   PV3814
MAPK3 (ERK1) 277   PV3311
MET (CMET) 236 PV3143
SRC 190 P3044
MERTK (cMER) A708S 83   PV6325
EGFR (ErbB1) 79 PV3872
JAK2 79 PV4210
YES1 79 A15557
ABL1 72 P3049
PINK1 69    
LRRK2 68 PV4873
PDK1 66   P3001
FYN 65 P3042
ABL2 (ARG) 64   PV3266
KIT 63 P3081
MAPK1 (ERK2) 58   PV3313
NTRK2 (TRKB) 57   PV3616
AKT1 (PKB alpha) 56   P2999
EIF2AK2 (PKR) 55   PV4821
TYK2 53   PV4790
CDK5/p25 52   PV4676
LKB1 52    
BCR 50    
PTK2 (FAK) 50 PV3832
JAK1 47   PV4774
CSF1R (FMS) 43   PV3249
ULK1 43   PV6430
LYN A 41 PV6448
TBK1 41   PV3504
ERN1 40   A30971
*Reflects the number of published papers discovered from a “common name kinase” + “specific disease area” keyword search in PubMed Central over the period from January 2000 to August 2016.

(Top)

Multiple Sclerosis research kinases

No records were found matching your criteria

Target Number of citations* Mutants/variants available? Cat. No.
PINK1 165    
LRRK2 162 PV4873
ROS1 100   PV3814
MET (CMET) 47 PV3143
MAPK3 (ERK1) 33   PV3311
CDK5/p25 20   PV4676
GAK 16   A30973
PLK2 15   PV4204
ABL2 (ARG) 14   PV3266
SRC 14 P3044
LRRK1 12    
MERTK (cMER) 11   PV3627
YES1 10   A15557
ERN1 9   A30971
PLK3 9   PV3812
MAPK1 (ERK2) 8   PV3313
EGFR (ErbB1) 7 PV3872
RET 7 PV3819
ULK1 7   PV6430
*Reflects the number of published papers discovered from a “common name kinase” + “specific disease area” keyword search in PubMed Central over the period from January 2000 to August 2016.

(Top)

Parkinson's disease research kinases

No records were found matching your criteria

Target Number of citations* Mutants/variants available? Cat. No.
MET (CMET) 215 PV3143
ERBB4 (HER4) 185   PV3626
MAPK3 (ERK1) 111   PV3311
NTRK2 (TRKB) 108   PV3616
AKT1 (PKB alpha) 102   P2999
SRC 91 P3044
FYN 63 P3042
ROS1 59   PV3814
CDK5/p25 53   PV4676
ErbB3 53    
YES1 46   A15557
MAPK1 (ERK2) 40   PV3313
EGFR (ErbB1) 39 PV3872
ABL2 (ARG) 25   PV3266
AKT3 (PKB gamma) 22   PV3185
CAMK2A (CaMKII alpha) 21   PV3142
FGFR1 21 PV3146
PAK1 21   PV3820
ERBB2 (HER2) 20   PV3366
GSK3B 20   PV3365
PTK2B (FAK2) 20   PV4567
LIMK1 18   PV4337
AKT2 (PKB beta) 17   PV3184
NTRK3 (TRKC) 17   PV3617
PAK3 17   PV3789
TNIK 17   PV6427
NTRK1 (TRKA) 16   PV3144
PDK1 16   P3001
CASK 15   PV6271
PINK1 14    
RET 14 PV3819
*Reflects the number of published papers discovered from a “common name kinase” + “specific disease area” keyword search in PubMed Central over the period from January 2000 to August 2016.

(Top)

Schizophrenia research kinases

Inflammation research kinases

Inflammation research

As our understanding of the mechanisms that control inflammatory responses improve, there is has been an increased emphasis on developing the next-generation inflammation drug candidates. Inflammatory diseases are associated with numerous debilitating diseases, including arthritis, inflammatory bowel disease, Crohn’s disease, psoriasis and atherosclerosis.

Thermo Fisher Scientific offers over 490 purified kinase proteins for therapeutic research and over 310 kinases that have been cited in over 27,000 published papers. Let our drug discovery products help you develop more effective anti-inflammatory drug candidates.

See the full list of mutants and kinases for inflammation research
Go to the kinase selection and ordering tool

No records were found matching your criteria

Target Number of citations* Mutants/variants available? Cat. No.
ROS1 4030   PV3814
MAPK3 (ERK1) 2501   PV3311
SRC 1683 P3044
MET (CMET) 1314 PV3143
EGFR (ErbB1) 1044 PV3872
JAK2 648 PV4210
MAPK8 (JNK1) 606   PV3319
ABL2 (ARG) 461   PV3266
SYK 439   PV3857
JAK1 418   PV4774
MAPK1 (ERK2) 390   PV3313
ATM 374    
YES1 371   A15557
EIF2AK2 (PKR) 367   PV4821
KIT 357 P3081
PTK2 (FAK) 354 PV3832
IRAK, pelle 351   PV4403
MERTK (cMER) 326   PV3627
BCR 309    
MAP3K14 (NIK) 301   PV4902
CSF1R (FMS) 297   PV3249
AKT1 (PKB alpha) 291   P2999
ABL1 276 P3049
LYN A 258 PV6448
TBK1 249   PV3504
FYN 233 P3042
PDK1 224   P3001
LCK 218   P3043
CDK4 (cyclin D1) 216   PV4400
JAK3 214   PV3855
*Reflects the number of published papers discovered from a “common name kinase” + “specific disease area” keyword search in PubMed Central over the period from January 2000 to August 2016.

(Top)

Inflammation research kinases

Metabolic disorders research kinases

Metabolic disorders research

As the worldwide obesity rate continues to grow, there has been an increase emphasis on studying the complications associated with metabolic disorders, like type II diabetes and hyperlipidemia. The roles of cell surface receptors and their respective signaling pathways have become increasingly more important in metabolic research, as these receptors are vital in the regulation of insulin and glucagon secretion. As a result, developing fast-acting compounds that can control the ways the body moderates metabolism and weight are at the forefront of many research endeavors.

Thermo Fisher Scientific offers over 490 purified kinase proteins for therapeutic research and over 300 kinases that have been cited in over 14,000 published papers. See the list of kinases for diabetes research and hyperlipidemia research below.

See the full list of mutants and kinases for metabolic disorders research
Go to the kinase selection and ordering tool

No records were found matching your criteria

Target Number of citations* Mutants/variants available? Cat. No.
ROS1 2458   PV3814
MAPK3 (ERK1) 1053   PV3311
MET (CMET) 980 PV3143
SRC 690 P3044
EGFR (ErbB1) 566 PV3872
LKB1 397    
PDK1 345   P3001
YES1 340   A15557
AKT1 (PKB alpha) 339   P2999
MAPK8 (JNK1) 293   PV3319
AKT2 (PKB beta) 282   PV3184
ABL2 (ARG) 268   PV3266
JAK2 254 PV4210
ERN1 235   A30971
MAP4K2 (GCK) 233   PV4211
EIF2AK2 (PKR) 227   PV4821
ATM 198    
p70S6K 193   PV6325
CDK5/p25 173   PV4676
INSR 169   PV3781
CDK4 (cyclin D1) 159   PV4400
MAPK1 (ERK2) 159   PV3313
IGF1R 138   PV3250
CDK2/Cyclin A 137 PV3267
KDR (VEGFR2) 120   PV3660
KIT 107 P3081
MERTK (cMER) 107   PV3627
PTK2 (FAK) 105 PV3832
BCR 97    
FYN 95 P3042
*Reflects the number of published papers discovered from a “common name kinase” + “specific disease area” keyword search in PubMed Central over the period from January 2000 to August 2016.

(Top)

Diabetes research kinases

No records were found matching your criteria

Target Number of citations* Mutants/variants available? Cat. No.
ROS1 101   PV3814
MAPK3 (ERK1) 35   PV3311
SRC 35 P3044
MET (CMET) 30 PV3143
LKB1 17    
AKT2 (PKB beta) 13   PV3184
YES1 13   A15557
FYN 11 P3042
JAK2 10 PV4210
LYN A 9 PV6448
PDK1 9   P3001
EGFR (ErbB1) 8 PV3872
MAPK8 (JNK1) 8   PV3319
AKT1 (PKB alpha) 7   P2999
SIK1 7 PV6445
SYK 7   PV3857
aPKC 6    
ERN1 6   A30971
FRAP1 (mTOR) 6   PV4753
*Reflects the number of published papers discovered from a “common name kinase” + “specific disease area” keyword search in PubMed Central over the period from January 2000 to August 2016.

(Top)

Hyperlipidemia research kinases

Respiratory disease research kinases

Respiratory disease research

With increasing focus on public health and air quality, a renewed importance has been placed on the study of chronic respiratory diseases including asthma, lung cancer and chronic obstructive pulmonary disease (COPD). 

Thermo Fisher Scientific offers over 490 purified kinase proteins for therapeutic research and over 210 kinases that have been cited in over 3,300 published papers. See the list of kinases for asthma research, chronic obstructive pulmonary disease (COPD) research, and cystic fibrosis research below.

See the full list of mutants and kinases for respiratory disease research
Go to the kinase selection and ordering tool

No records were found matching your criteria

Target Number of citations* Mutants/variants available? Cat. No.
MAPK3 (ERK1) 218   PV3311
ROS1 209   PV3814
SRC 145 P3044
MET (CMET) 108 PV3143
EGFR (ErbB1) 103 PV3872
KIT 70 P3081
SYK 68   PV3857
JAK2 61 PV4210
YES1 59   A15557
ABL2 (ARG) 53   PV3266
JAK1 53   PV4774
LYN A 48 PV6448
BCR 36    
FYN 33 P3042
JAK3 30   PV3855
LCK 30   P3043
MAPK1 (ERK2) 30   PV3313
TYK2 30   PV4790
CSF1R (FMS) 28   PV3249
MAPK8 (JNK1) 28   PV3319
TEC 28   PV3269
AKT1 (PKB alpha) 26   P2999
EIF2AK2 (PKR) 26   PV4821
FLT3 26 PV3182
ABL1 24 P3049
ALK 24 PV3867
TNK2 (ACK) 23   PV4807
BTK 22   PV3363
MERTK (cMER) 22   PV3627
PTK2 (FAK) 20 PV3832
*Reflects the number of published papers discovered from a “common name kinase” + “specific disease area” keyword search in PubMed Central over the period from January 2000 to August 2016.

(Top)

Asthma research kinases

No records were found matching your criteria

Target Number of citations* Mutants/variants available? Cat. No.
MAPK3 (ERK1) 81   PV3311
EGFR (ErbB1) 74 PV3872
MET (CMET) 56 PV3143
SRC 42 P3044
YES1 25   A15557
EIF2AK2 (PKR) 20   PV4821
ROS1 20   PV3814
PTK2 (FAK) 13   PV3832
PTK2B (FAK2) 13   PV4567
ATM 11    
MAPK8 (JNK1) 11   PV3319
MERTK (cMER) 11   PV3627
ABL1 10 P3049
JAK2 10 PV4210
RAF1 (cRAF) Y340D Y341D 10 PV3805
ALK 9 PV3867
MAPK1 (ERK2) 9   PV3313
TNK2 (ACK) 9   PV4807
ABL2 (ARG) 8   PV3266
MERTK (cMER) A708S 8   PV6325
BMPR2 7   PV6256
ERBB2 (HER2) 7   PV3366
IRAK, pelle 7   PV4403
SYK 7   PV3857
ULK1 7   PV6430
*Reflects the number of published papers discovered from a “common name kinase” + “specific disease area” keyword search in PubMed Central over the period from January 2000 to August 2016.

(Top)

COPD research kinases

No records were found matching your criteria

Target Number of citations* Mutants/variants available? Cat. No.
ROS1 72   PV3814
MET (CMET) 64 PV3143
MAPK3 (ERK1) 56   PV3311
ABL2 (ARG) 38   PV3266
SRC 36 P3044
EGFR (ErbB1) 35 PV3872
YES1 27   A15557
MERTK (cMER) 20   PV3627
SGK (SGK1) 20   PV3818
Wnk1 17   A33513
OXSR1 15   A30983
EIF2AK2 (PKR) 14   PV4821
ERN1 14   A30971
MAPK1 (ERK2) 12   PV3313
SYK 11   PV3857
Wnk4 10    
LKB1 9    
PTK2B (FAK2) 9 PV3832
ERBB2 (HER2) 8   PV3366
ATM 7    
Wnk3 7   PV4342
*Reflects the number of published papers discovered from a “common name kinase” + “specific disease area” keyword search in PubMed Central over the period from January 2000 to August 2016.

(Top)

Cystic Fibrosis research kinases

Kinase selection guide

{{column.ids[1]}}

  • {{value}}
Area Area Target Number of citations Variant Catalog No. Add to cart
{{row["area+0"]}} {{row["area+1"]}} {{row["target+2"]}} {{row.number}} {{row.variant}} {{row.sku}}