Androgen receptors are transcription factors belonging to the nuclear receptor superfamily. They are expressed in bone marrow, mammary gland, brain, hair follicles, cardiovascular, prostate, testicular and muscle tissues where they exist as dimers coupled to accessory proteins, which are shed upon ligand binding.
When activated by ligand binding, androgen receptors stimulate the transcription of androgen responsive genes. Androgen receptors play an essential role in male development including development of primary and secondary male sexual characteristics during embryogenesis and puberty, maintenance of sexual function, and may play a causal role in aggressive behavior.
Congenital mutations in androgen receptors are linked with androgen insensitivity syndromes, virility problems, and spinal and bulbar muscular atrophy. Changes in androgen receptor expression are also associated with prostate cancer. Androgen receptor antibodies aid in the detection and study of the androgen receptor and its functions. Quality Invitrogen androgen receptor antibodies are available for your research needs.