Cyclophilin A (CypA) is a member of the cyclophilin family of peptidylprolyl isomerases. CypA participates in protein folding and intracellular protein transport. Like the other cyclophilins, cyclophilin A is a cyclosporin binding protein and has a part in cyclosporin A-mediated immunosuppression. Cyclophilin A also interacts with several HIV proteins and has been shown to be required for the formation of infectious HIV virions.

Cyclophilin A is an excellent western blot loading control as it is the most abundant and ubiquitous cyclophilin in vertebrate tissue. We offer a number of quality Invitrogen cyclophilin A antibodies for a variety of research needs.

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Immunohistochemical analysis of cyclophilin A in paraffin-embedded SW480 xenograft. A cyclophilin A polyclonal antibody (Cat. No. PA5-29752) was used at a dilution of 1:100.


Immunofluorescent analysis of cyclophilin A in methanol-fixed HeLa cells. A cyclophilin A polyclonal antibody (Cat. No. PA5-28089) was used at a dilution of 1:200. Bottom panel is co-stained with Hoechst™ 33342 dye