Intermediate filaments are a diverse group of proteins that grant structure and function to the cytoskeleton. At about 10 nm in diameter, they are intermediate between the diameters of actin filaments and microtubules, the two other major components of the cytoskeleton. Similar to actin, intermediate filaments maintain cell shape by giving rigidity and bearing tension. Intermediate filaments assist in organizing the internal three-dimensional structure of the cell, anchoring organelles and the nucleus in place, and helping form some cell–cell and cell–matrix junctions. Intermediate filaments are not directly involved in cell movement, and because they are plentiful in cells subjected to mechanical stress, their primary role appears to be strengthening cells and tissues. Intermediate filaments are also structural parts of the nuclear lamina that lines the inside of the nuclear membrane and directs the shape of the nucleus. The six major types of intermediate filaments are distinguished and expressed in particular cell types.
Intermediate filament marker antibodies detect proteins specific to intermediate filaments and can aid in the study of their structure and function. Intermediate Filament marker antibodies can also help elucidate the role or roles a protein may play in a number of tasks that are centered in or influenced by intermediate filaments. Quality Invitrogen intermediate filament marker antibodies are available for a variety of research needs.