Informatics to help guide decisions in cancer research

Managing, and ultimately interpreting, the significant quantities of variant data produced by next-generation sequencing (NGS) presents a formidable challenge. In oncology specifically, the wide range of variants in tumor samples presents challenges for efficient, accurate, and thorough analysis of cancer-relevant data.

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Oncomine informatics helps you:

  • Prioritize variants, find the relevant few
  • Calls variants, identify and annotate cancer drivers
  • Quickly create custom, lab-generated reports


Oncomine informatics products

Oncomine Knowledgebase Reporter

Whether you are in a high volume lab or in a highly collaborative, multi-site organization, Oncomine Knowledgebase Reporter has the implementation to fit your needs from a local server to the latest web-based version available in Thermo Fisher Connect powered by Thermo Fisher Cloud.

The web-based Oncomine Knowlegebase Reporter, available in Thermo Fisher Connect, enables a secure, scalable analysis platform with a pay-as-you-go reporting structure.

  • Curated, relevant evidence links gene variants to relevant labels, guidelines, and global clinical trials
  • Easy-to-use interface allows user to generate a report in a few steps: upload, filter, and report
  • Customizable report templates available in ten languages

Oncomine Knowledgebase Reporter helps you find the relevant few cancer drivers in a report that enables contextual investigation of sample-specific variants to understand their use with respect to labels, guidelines, and current global clinical trials. It is a genomic analysis tool developed specifically for further examination of NGS data, enabling streamlined access to a final report in three easy steps: upload variants for cancer research, filter for curated content matching your source data, and create a custom report (Figure 1) for your laboratory.

Oncomine Knowledgebase Reporter requires VCF or ZIP files from Ion Reporter Software and supports these Ion Torrent assays:

  • Oncomine Focus Assay
  • Oncomine Comprehensive Assay
  • Oncomine Breast cfDNA Assay
  • Oncomine Colon cfDNA Assay
  • Oncomine Lung cfDNA Assay
  • Oncomine BRCA Research Assay

Figure 1. Customizable report. The report header and footer contain many customizable fields. The Variant Summary presents the sample-specific data by source and variant. In the Relevant Therapy Summary, the easy-to-read legend continues as more details on each variant are presented.

Ion Reporter Software and Oncomine Variant Annotator Plug-in

Simplify your bioinformatics path to discovery with Ion Reporter Software. By helping to remove barriers in NGS data analysis, this software enables you to focus on finding the biological meaning of your data.

  • Plug-in helps you find the relevant few cancer drivers based on information in the Oncomine Knowledgebase
  • Plug-in classifies each variant as gain-of-function or loss-of-function, based on analysis of >5,300 tumor-normal pair exomes across 48 types of cancers from the Oncomine Knowledgebase
  • Plug-in enables a tumor-only workflow
  • Ion Reporter Software provides easy data analysis across a variety of research applications
  • Ion Reporter Software provides fast results with optimized workflows and user tools

About the Oncomine Knowledgebase

Gather, evaluate, standardize, analyze, inform, repeat
To inform and drive drug discovery and companion diagnostic development programs, the vast genomic data sets produced by NGS studies must be analyzed, annotated, and ultimately interpreted by experienced bioinformaticians.

Oncomine Knowledgebase Reporter is a meticulously curated set of data from from global clinical trials as well as labels and guidelines from the US and Europe that enables custom, sample-specific reporting.

  • Enables linking variants to labels, guidelines, and global clinical trials
  • Informs the design of Oncomine assays 
  • Updated quarterly

The Oncomine Knowledgebase is a robust, curated, and verified database containing cancer genomic data that enables targeted assay design:

  • Informs the design of Oncomine assays
  • Informs the Oncomine Variant Annotator plug-in
  • Gathers data from public sources, peer-reviewed literature, and authors
  • Drives the data behind the Oncomine Platform Software

Oncomine Platform Software

Enabling a powerful set of analysis functions that compute gene expression signatures, clusters, and gene-set modules, Oncomine Platform Software automatically extracts biological insights from data.

  • Information that enables novel cancer discoveries
  • Insight that may help you publish faster