Cell Structure Information

Find useful articles, videos and tools for studying cell structure using fluorescence microscopy and high-content analysis.

Cell structure features

On-demand webinar

Introduction to basic cytoskeleton labeling and detection

This webinar provides an overview of the cytoskeleton and includes a comprehensive guide to labeling and detection technologies such as live-cell imaging fluorescent dyes, antibodies and the BacMam gene delivery platform.

BioProbes article

Tools to study mitochondrial morphology and function—Multiplex your mitochondrial data

We highlight a few of our most referenced mitochondrial probes for studying cell morphology and function.


Cell structure learning resources

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Type Title Categories
Application note (2011) Apoptosis detection: Apoptosis assays for the Attune Acoustic Focusing Cytometer  Alexa Fluor, apoptosis, Attune/Attune NxT, cell structure-mitochondria, cell structure-plasma membrane, flow cytometer/flow cytometry, fluorescent dyes
Application note (2015) Collecting Z-stack image sequences with the EVOS FL Auto Imaging System cell structure-all, CellLight, EVOS FL Auto Microscope, fluorescence microscopy/fluorescence imaging, live-cell imaging, ReadyProbes
BioProbes article (2006) Tools for membrane research  cell structure-mitochondria, cell structure-plasma membrane, cell tracking, flow cytometer/flow cytometry, fluorescent dyes, fluorescence microscopy/fluorescence imaging, lipids
BioProbes article (2006) Reagents and assays for high-content screening  cell structure-nucleus, cell structure-plasma membrane, fluorescent dyes, high content analysis, fluorescence microscopy/fluorescence imaging
BioProbes article (2007) Seeing superoxide in a radical new light  cell structure-mitochondria, fluorescent dyes, fluorescence microscopy/fluorescence imaging, live-cell imaging, oxidative stress, sample stability
BioProbes article (2007) Mitochondria and cardiac disorders  antibodies, antibody labeling, cardiovascular system, cell structure-mitochondria, fluorescent dyes, fluorescence microscopy/fluorescence imaging, oxidative stress, western blotting
BioProbes article (2007) Cells from the inside out  cell structure-all, flow cytometer/flow cytometry, fluorescent proteins, fluorescence microscopy/fluorescence imaging, in vivo imaging, multicolor flow cytometry, nanocrystals, Qdot
BioProbes article (2007) Investigating apoptosis-induced loss of SYTO dye fluorescence  apoptosis, cell structure-mitochondria, enzyme activity detection, flow cytometer/flow cytometry, fluorescent dyes
BioProbes article (2007) Multiparametric approaches for studying apoptosis  Alexa Fluor, antibodies, apoptosis, cell structure-mitochondria, cell structure-plasma membrane, enzyme activity detection, flow cytometer/flow cytometry, fluorescent dyes, viability
BioProbes article (2008) Fluorescent protein–based Organelle Lights and new Cellular Lights BacMam reagents  BacMam technology, cell structure-all, cell tracking, Cellular Lights, fluorescent proteins, fluorescence microscopy/fluorescence imaging, immunocytochemistry (ICC)
BioProbes article (2008) Seeing clearly: Accurate cell identification—CellMask stains for fluorescence-based imaging  cell structure-cytoplasm, cell structure-nucleus, cell structure-plasma membrane, fluorescent dyes,  fluorescence microscopy/fluorescence imaging, high content analysis, live-cell imaging
BioProbes article (2009) Multiparametric approaches for predictive hepatotoxicity  cell structure-mitochondria, cell structure-plasma membrane, flow cytometer/flow cytometry, fluorescent dyes, fluorescence microscopy/fluorescence imaging, high content analysis, oxidative stress, viability
BioProbes article (2009) Nanotechnology meets cellular analysis  cell structure-all, flow cytometer/flow cytometry, fluorescent dyes, fluorescence microscopy/fluorescence imaging, media, multicolor flow cytometry, nanocrystals, Qdot, sample stability
BioProbes article (2009) Mitochondrial fission and fusion in neurodegeneration  antibodies, BacMam technology, cell structure-mitochondria, flow cytometer/flow cytometry, fluorescent dyes, fluorescent proteins, fluorescence microscopy/fluorescence imaging, microplate reader, neuroscience
BioProbes article (2009) Lights. Cells. Action. Organelle Lights and Cellular Lights reagents   BacMam technology, cell structure-all, Cellular Lights, fluorescent proteins, fluorescence microscopy/fluorescence imaging, live-cell imaging
BioProbes article (2009) Modeling mammary cell function in three dimensions  BacMam technology, cell culture, cell structure-actin, cell structure-golgi, Cellular Lights, fluorescent proteins, Gibco, fluorescence microscopy/fluorescence imaging, membranes, particles, sample preparation
BioProbes article (2009) Staining DNA without altering its structure  cell structure-nucleus, flow cytometer/flow cytometry, fluorescent dyes, fluorescence microscopy/fluorescence imaging, live-cell imaging, nucleic acid detection
BioProbes article (2010) Biology in context—Transforming live-cell microscopy with CellLight reagents cell structure, CellLight fluorescence microscopy/fluorescence imaging, fluorescent proteins, high content analysis, live-cell imaging
BioProbes article (2010) Probes for visualizing secretory transport and autophagy autophagy, cell structure, cell structure-ER, cell structure-golgi, cell structure-mitochondria, CellLight, fluorescence microscopy/fluorescence imaging, high content analysis
BioProbes article (2010) A closer look at mitochondrial dysfunction with MitoSOX Red Mitochondrial Superoxide Indicator cell structure-mitochondria, oxidative stress
BioProbes article (2010) Mitochondrial DNA synthesis exposed Click-iT, cell proliferation, cell structure-mitochondria
BioProbes article (2010) Alexa Fluor dyes shed light on a new actin assembly factor cell structure-actin, fluorescence microscopy/fluorescence imaging, high content analysis, oxidative stress
BioProbes article (2011) Detection of actin, intermediate filaments, and tubulin—Imaging a dynamic cellular scaffold cell structure, cell structure-actin, CellLight fluorescence microscopy/fluorescence imaging, high content analysis
BioProbes article (2011) Advances in high-content screening—Assays for multiparametric analysis of cell health ArrayScan, cell health, cell proliferation, cell structure-plasma membrane, Click-iT EdU, fluorescence microscopy/fluorescence imaging, high content analysis, viability
BioProbes article (2011) Explore the powerhouse—Probes for mitochondrial morphology and function cell structure, cell structure-mitochondria CellLight, fluorescence microscopy/fluorescence imaging, high content analysis
BioProbes article (2011) Endocytosis in disease and cell health cell health, cell structure, CellLight, endocytosis and phagocytosis, fluorescence microscopy/fluorescence imaging, high content analysis, pH detection
BioProbes article (2012) From exosome isolation to biomarker discovery—Total exosome isolation reagents for a complete exosome workflow exosomes, RNA isolation, sequencing
BioProbes article (2012) Breakthrough tools for epigenetics studies—Structural Genomics Consortium and Life Technologies collaborate on first antibody master set antibodies, cell structure-nucleus, ChIP, epigenetics
BioProbes article (2012) On-the-spot imaging and processing EVOS, brightfield microscopy, cell structure-actin fluorescent proteins, cell structure-nucleus, fluorescence microscopy/fluorescence imaging, high content analysis
BioProbes article (2012) Ready-to-use reagents shift the focus to results cell structure-nucleus, fluorescence microscopy/fluorescence imaging, high content analysis, sample preparation, viability
BioProbes article (2012) Automating cell biology—Create your own HCS assay using trusted Molecular Probes dyes antibodies, antibody labeling, cell structure, cell structure-actin, cell structure-lysosomes, cell structure-mitochondria, CellLight, fixed-cell imaging, fluorescence microscopy/fluorescence imaging, high content analysis
BioProbes article (2012) Unmasking cell replication—Reagents for analyzing cell cycle and replication in mammalian cells cell cycle, cell health cell proliferation, cell structure-nucleus, Click-iT, flow cytometer/flow cytometry, fluorescence microscopy/fluorescence imaging
BioProbes article (2013) ReadyProbes ready-to-use imaging reagents for brilliant results apoptosis, cell structure-all, fluorescence microscopy/fluorescence imaging, high content analysis, reagents, Imaging sample preparation, viability
BioProbes article (2013) The EVOS FL Auto Imaging System—Automated imaging. Simplified brightfield microscopy, cell structure-all, EVOS, fluorescence microscopy/fluorescence imaging
BioProbes article (2013) Autophagy made visible—Advanced fluorescent probes for imaging distinct processes in the autophagy pathway autophagy, cell structure, cell structure-lysosomes, CellLight, fluorescence microscopy/fluorescence imaging, high content analysis
BioProbes article (2014) Image live cells through time and space—Optimizing conditions for time-lapse fluorescence microscopy cell structure, cell tracking, CellLight, EVOS, fluorescence microscopy/fluorescence imaging, high content analysis, live-cell imaging, oxidative stress
BioProbes article (2014) Journal Club—An in-depth Look at fluorescent dyes for organelle labeling cell structure-all, fluorescence microscopy/fluorescence imaging, fluorescent dyes
BioProbes article (2015) Tools to study mitochondrial morphology and function—Multiplex your mitochondrial data cell structure-mitochondria, fluorescence microscopy/fluorescence imaging, oxidative stress
BioProbes article (2015) CellInsight CX7 High Content Analysis Platform—Accessible technology for high-content analysis ArrayScan, brightfield microscopy, cell structure CellInsight, high content analysis
BioProbes article (2015) Isolation and characterization of exosomes using magnetic beads antibodies, exosomes, flow cytometer/flow cytometry,immunophenotyping, multiplex ELISA/Luminex,  particles, protein blotting, western detection
BioProbes article (2015) Journal Club—Multiparameter detection of early apoptosis markers without compensation apoptosis, Attune/Attune NxT, cell structure-mitochondria, flow cytometer/flow cytometryimmunophenotyping
Molecular Probes Handbook Mitochondria in diseases—Note 12.2 antibodies, cell structure-mitochondria, fluorescence microscopy/fluorescence imaging
Molecular Probes Handbook Lipid-mixing assays of membrane fusion—Note 13.1 cell structure-plasma membrane, fluorescent lipids, membranes, micelles
Molecular Probes Handbook Assays of volume change, membrane fusion and membrane permeability—Note 14.3 cell structure-plasma membrane, fluorescent lipids, membranes, micelles
Molecular Probes Handbook Antibodies for detecting membrane-surface labels—Note 13.2 antibodies, cell structure-plasma membrane, extracellular proteins
Molecular Probes Handbook Probes for the endoplasmic reticulum and golgi apparatus—Section 12.4 antibodies, cell structure-er, cell structure-golgi, fluorescence microscopy/fluorescence imaging, fluorescent dyes
Molecular Probes Handbook Probes for mitochondria—Section 12.2 antibodies, cell structure-mitochondria, CellLight, flow cytometer/flow cytometry, fluorescence microscopy/fluorescence imaging, fluorescent dyes
Molecular Probes Handbook Probes for lysosomes, peroxisomes and yeast vacuoles—Section 12.3 antibodies, cell structure-lysosomes, CellLight, flow cytometer/flow cytometry, fluorescence microscopy/fluorescence imaging, fluorescent dyes
Molecular Probes Handbook Probes for the nucleus—Section 12.5 antibodies, cell structure-nucleus, CellLight, flow cytometer/flow cytometry, fluorescence microscopy/fluorescence imaging, fluorescent dyes, membrane permeability
Molecular Probes Handbook A diverse selection of organelle probes—Section 12.1 cell structure-er, cell structure-golgi, cell structure-lysosomes, cell structure-mitochondria, cell structure-nucleus, cell structure-plasma membrane, fluorescence microscopy/fluorescence imaging
Molecular Probes Handbook Introduction to potentiometric probes—Section 22.1 cell structure-plasma membrane, fast-response probes, fluorescence microscopy/fluorescence imaging, fluorometer, ion channels, live-cell imaging, membrane potential, slow-response probes
Molecular Probes Handbook Fast-response probes—Section 22.2 cell structure-plasma membrane, fast-response probes, fluorescence microscopy/fluorescence imaging, fluorometer, ion channels, live-cell imaging, membrane potential
Molecular Probes Handbook Other nonpolar and amphiphilic probes—Section 13.5 carbocyanine dyes, cell structure-plasma membrane, DiI, fluorescence microscopy/fluorescence imaging, fluorescent lipid dyes, fluorometer
Molecular Probes Handbook Introduction to membrane probes—Section 13.1 cell structure-plasma membrane, fast-response probes, fluorescence microscopy/fluorescence imaging, fluorometer, ion channels, live-cell imaging, membrane potential, slow-response probes
Molecular Probes Handbook Fatty acid analogs and phospholipids—Section 13.2 cell structure-plasma membrane, fluorescence microscopy/fluorescence imaging, fluorescent fatty acid analogs, fluorescent lipid dyes, fluorometer
Molecular Probes Handbook Dialkylcarbocyanine and dialkylaminostyryl probes—Section 13.4 carbocyanine dyes, cell structure-plasma membrane, DiI, fluorescence microscopy/fluorescence imaging, fluorescent lipid dyes, fluorometer
Molecular Probes Handbook Probes for neurotransmitter receptors—Section 16.2 brain hormones, cell structure-plasma membrane, fluorescence microscopy/fluorescence imaging, fluorescent dyes, receptor binding
Molecular Probes Handbook Probes for following receptor binding and phagocytosis—Section 16.1 cell structure-plasma membrane, fluorescence microscopy/fluorescence imaging, fluorescent dyes, internalization, membrane trafficking, phagocytosis, receptor binding, vesicle
Molecular Probes Handbook Probes for tubulin and other cytoskeletal proteins—Section 11.2 cell structure-tubulin, cytoskeleton, fluorescence microscopy/fluorescence imaging, fluorescent dyes, fluorescent proteins
Molecular Probes Handbook Probes for actin—Section 11.1 cell structure-actin, cytoskeleton, fluorescence microscopy/fluorescence imaging, fluorescent dyes, fluorescent proteins
Molecular Probes Handbook Nucleic acid stains—Section 8.1 cell cycle, cell structure-nucleus, cell structure-plasma membrane, cell viability, DAPI, DNA binding dyes, flow cytometer/flow cytometry, fluorescence microscopy/fluorescence imaging, fluorescent dyes, fluorometer, membrane permeability, RNA binding dyes, SYTO, SYTOX
Molecular Probes Handbook Tracers for membrane labeling—Section 14.4 cell structure-plasma membrane, cell tracking, flow cytometer/flow cytometry, fluorescence microscopy/fluorescence imaging, live-cell imaging
Protocol TO-PRO-3 Stain cell structure, imaging
Protocol SYTOX Green Nucleic Acid Stain cell structure, imaging
Protocol SYTO 82 Nuclear Stain cell structure, imaging
Protocol SYTO 59 Nuclear Stain cell structure, imaging
Protocol NucRed Live 647 ReadyProbes Reagent cell structure, imaging
Protocol NucRed Dead 647 ReadyProbes Reagent for fixed cells cell structure, imaging
Protocol NucGreen Dead 488 ReadyProbes Reagent for fixed cells cell structure, imaging
Protocol NucBlue Live ReadyProbes Reagent cell structure, imaging
Protocol NucBlue Fixed Cell ReadyProbes Reagent cell structure, imaging
Protocol Hoechst 33342 for imaging cell structure, imaging
Protocol Hoechst 33342 for HCA instruments cell structure, high content analysis
Protocol HCS NuclearMask Red Stain cell structure, high content analysis
Protocol HCS NuclearMask Deep Red Stain cell structure, high content analysis
Protocol HCS NuclearMask Blue Stain cell structure, high content analysis
Protocol HCS CellMask Stains cell structure, high content analysis
Protocol DAPI for fluorescence imaging cell structure, imaging
Protocol DAPI for HCA instruments cell structure, high content analysis
Protocol ActinRed 555 ReadyProbes Reagent cell structure, imaging
Protocol ActinGreen 488 ReadyProbes Reagent cell structure, imaging
Scientific poster (2009) Cell-based assays for predictive hepatotoxicity measurements using high content imaging  Alexa Fluor, ArrayScan, cell structure-plasma membrane, Click-iT, fluorescence microscopy/fluorescence imaging, fluorescent dyes, glutathione, high content analysis, microplate reader, nucleic acid quantitation, viability
Scientific poster (2009) High content imaging and analysis of mitotoxicity and cytotoxicity in fixed cells  cell structure-mitochondria, fluorescence microscopy/fluorescence imaging, fluorescent dyes, high content analysis, viability
Scientific poster (2010) Autophagosomal accumulation perturbs Golgi structure without affecting other organelles: Implications for autophagosome biogenesis  Alexa Fluor, antibodies, autophagy, BacMam technology, cell structure-golgi, Click-iT, fluorescence microscopy/fluorescence imaging, fluorescent dyes, high content analysis, live-cell imaging
Scientific poster (2014) New fluorescent probes and sensors for visualizing endocytosis, lysosomal dynamics and autophagy  autophagy, cell structure-lysosomes, endocytosis/phagocytosis, autophagy, fluorescence microscopy/fluorescence imaging, high content analysis, microplate reader
Video Viability determination of HeLa cells using ReadyProbes Cell Viability Imaging Kit (Blue/Green) 
HeLa cells were loaded with NucBlue Live and NucGreen Dead (using 2 drops per ml) in complete media for 15 minutes at 37C. Stauroporine was then added to a final concentration of 1 µM and images were acquired every 30 min. for 18 hours using EVOS Auto Imaging System. All cells are stained with NucBlue Live, shown with blue nuclei. Over time an increase in the number of dead cells is observed as indicated by the appearance of green nuclei (NucGreen Dead).
cell structure-nucleus, cell viability, fluorescence microscopy/fluorescence imaging, live-cell imaging
Video CellTracker Violet reagent and mitosis  
U-2 OS cells were transduced with CellLight Tubulin-GFP and Cellular Lights Actin-RFP. The following day cells were labeled with 5uM CellTracker Violet BMQC for 30 minutes at 37C in complete media and washed in fresh media. Images were taken every 5 minutes for 16 hours.
cell structure-all, cell tracking, fluorescence microscopy/fluorescence imaging, live-cell imaging
Video Compilation of live cell imaging videos using Invitrogen fluorescent reagents 
This video demonstrates novel product brands from Invitrogen for live cell imaging include CellLight targeted fluorescent proteins, CellROX reagents for oxidative stress, CellEvent caspase 3/7 detection reagent, and many more fluorescent dyes and probes.
cell structure-mitochondria, CellEvent, CellLight, CellROX, fluorescence microscopy/fluorescence imaging, live-cell imaging, oxidative stress
Video Z Stack image of HeLa cells labeled with CellLights reagents 
A series of images were captured on the EVOS FL Auto Cell Imaging System. Creating a Z-stack from these images allowed the observation of cellular cytoskeletal changes, which can be indicative of the loss of cell health. Methods HeLa cells grown in MatTek 6-well glass bottom culture plates were transduced with CellLights Tubulin-GFP and CellLight Mitochondria-RFP overnight at 37oC. The following day, NucBlue Live reagent (2 drops/mL) was added to the cultures. Cells were then imaged on an EVOS FL Auto Cell Imaging System with 100x oil immersion objective using the Z-stack function. The step size was set using the Nyquist formula and performed at 0.366 μm.
cell health, cell structure-all, CellLight, EVOS FL Auto Microscope, fluorescence microscopy/fluorescence imaging, fluorescent proteins, live-cell imaging
Video Mitochondrial dynamics through cell division 
U2OS cells were transduced with CellLight Mito-RFP and imaged every 5 minutes for 16 hours. Extensive mitochondrial motility is seen throughout mitosis and as the cell regains it's pre mitotic shape following mitosis.
cell structure-mitochondria, CellLight, fluorescence microscopy/fluorescence imaging, live-cell imaging
Video Exosomes—The Next Small Thing: Episode 5—Collaboration—The key to scientific success Exosomes
Video Exosomes—The Next Small Thing: Episode 6—Exosomes the next small thing Exosomes
Video Exosomes—The Next Small Thing: Episode 4—Curiosity and a passion for science Exosomes
Video Exosomes—The Next Small Thing: Episode 3—Exosomes in cancer research Exosomes
Video Exosomes—The Next Small Thing: Episode 2—The history and promise of an exosome Exosomes
Video Exosomes—The Next Small Thing: Episode 1—What is an exosome? Exosomes
Webinar Introduction to basic cytoskeleton labeling and detection 
The cytoskeleton is a key component of mammalian cells, providing the framework for cell migration and intracellular transport, furthermore the cytoskeleton regulates cell size and shape as well as important processes such as mitosis and endocytosis. We offer a number of solutions for researchers using fluorescent probes to study the cytoskeleton. This webinar will provide an overview of the structures that comprise the cytoskeleton and important experimental parameters. The webinar also offers a comprehensive guide to available labeling and detection technologies for cytoskeletal research as well as tips and tricks on how to best use them. These tools include those for live-cell imaging fluorescent dyes, antibodies and the BacMam gene delivery platform.
cell structure-actin, cytoskeleton, endocytosis, fluorescence microscopy/fluorescence imaging, fluorescent dyes, fluorescent proteins