Image of a scientist at a high-content screening instrument

Automated imaging and analysis platforms

High-content screening (HCS) or high-content analysis (HCA) requires an instrument designed to extract the maximum information from your sample in a robust and reproducible manner with the speed for high-throughput analysis. 

The entire Thermo Scientific™ portfolio of HCS instruments helps deliver on those parameters and includes:

  • Superior illumination—the LED light engine reduces intensity fluctuations and optical component wear, eliminates moving parts, and reduces both integration and channel switching times
  • Precise image capture—the highly sensitive, 14-bit cooled X1 CCD camera with enlarged 2,208 x 2,208 pixel array captures quantitative data with high quantum efficiency across the spectrum
  • Rapid data analysis—Thermo Scientific™ HCS Studio™ software analyzes your images in real time, so that you collect all the data you need to make decisions that count
  • Reagent compatibility—Thermo Scientific HCS platforms build on the expertise of Molecular Probes™ in reagent development with exquisite fluorescent tools for interrogating the biology of the cell

Find the system that fits your laboratory

CellInsight CX5 Platform

Compact screening system to scale up your throughput

photo of the CellInsight CX5 instrument

Find reagents for use with CellInsight CX5 Platform

CellInsight CX7 Platform

Integrated performance modes for screening and analysis

photo of the CellInsight CX7 instrument

Find reagents for use with CellInsight CX7 Platform

ArrayScan Systems

Modular solutions to address specialized applications

photo of the ArrayScan hcs instrument

Find reagents for use with ArrayScan Systems

Why Thermo Scientific HCA Systems?

Since the founding of Cellomics in 1999 and the introduction of the ArrayScan Systems, over 900 peer-reviewed publications attest to a legacy of innovation in high-content analysis (HCA) that continues with the Thermo Scientific CellInsight CX7 High-Content Platform. Thermo Fisher Scientific also incorporates the expertise of Molecular Probes™ labeling technologies in developing and manufacturing exquisite fluorescent tools for interrogating the biology of the cell.

Find applications in our extensive bibliography—from toxicology assays to cell phenotyping—that will validate your strategy and inform the next steps in your research. Download a section from one of the links below, or scan through the bibliography. Note that any reagents you select will have associated publications listed on their respective detail pages.

Download publication lists:

HeLa cells imaged using the CellInsight™ CX5

Rat cortical neuron image acquired using a Thermo Scientific™ ArrayScan™ system and stained with DAPI (blue), anti-MAP2 and Invitrogen™ Alexa Fluor™ 488 goat anti–mouse IgG (green), and anti-synaptophysin and Invitrogen™ Alexa Fluor™ 647 goat anti–rabbit IgG (red).

HeLa cells imaged using the CellInsight CX7 platform

HeLa cell image acquired using the Thermo Scientific™ CellInsight™ CX7 platform and stained with Invitrogen™ HCS NuclearMask™ Blue (blue), Invitrogen™ MitoTracker™ Orange (green), and Invitrogen™ Alexa Fluor™ 647 Phalloidin (red).

video of CHO cells acquired using the ArrayScan™ system

CHO cells stably expressing GFP-tagged GLUT4 acquired using a Thermo Scientific™ ArrayScan™ system. The movie shows trafficking of GLUT4 in intracellular vesicles from the cytoplasm to the plasma membrane and ruffling of the plasma membrane.

Which HCA system is right for you?

 

Compact screening system to scale up your throughput

photo of CellInsight CX5 HCS platform

CellInsight CX5 Platform

Integrated performance modes for screening and analysis

photo of CellInsight CX7 HCS platform

CellInsight CX7 Platform

Modular solutions to address specialized applications

photo of ArrayScan XTI HCA Instrument

ArrayScan Systems

Illumination 5 channels 7 channels 7 channels
Camera Photometrics™ X1 Photometrics™ X1 Photometrics™ X1
Widefield 5 channels 7 channels 7 channels
Brightfield White White + 4 colors White (optional)
Confocal NA 7 channels 7 channels (optional)
Objectives 1-position turret
2x to 20x
3-position turret
2x to 40x
4-position turret
1.25x to 63x
Focus Software Laser and software Laser and software
Live cell NA NA Live cell (optional)
Software HCS Studio™ 2.0 Cell Analysis Client Software HCS Studio™ 2.0 Cell Analysis Client Software HCS Studio™ 2.0 Cell Analysis Client Software
Thermo Fisher Cloud
Save files to Cloud through computer
Database Store™ Image and Database Management Software (optional) Store™ Image and Database Management Software (optional) Store™ Image and Database Management Software (optional)