Genome Editing Webinars

In this synthetic biology webinars module, our scientists and collaborators will cover genome editing in particular technologies, techniques, and applications. The webinars are designed to give a basic framework for learning these technologies. Each webinar also provides background information, data analysis, and helpful tips from our experienced technical support scientists and collaborators.

Recorded Genome Editing webinars


CRISPR-Cas9 design to analysis in 4 days

Join us for this webinar where we discuss the complete CRISPR editing solution designed to expedite your research. With easy-to-use, optimized, and validated solutions that span the entire cell engineering workflow in just 4 days, genome editing is now accessible to anyone at any level.

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How to boost your CRISPR editing efficiency

CRISPR-Cas9 is rapidly evolving as the tool of choice for genome editing in mammalian cells. The design and synthesis of guide RNA (gRNA), as well as the difficulty of delivering Cas9 into various cell lines, are steps that limit overall efficiency and general ease of use. In this webinar, we describe a new state-of-the-art online CRISPR gRNA design tool that allows for rapid identification of gRNAs that have low off-target potential.

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CRISPR-generated human knockout cell lines, empowering your research

Join us for our webinar, “CRISPR-Generated Human Knockout Cell Lines, empowering your research”. CRISPR-Cas9 technology is revolutionizing biological research and enabling the creation of precisely engineered cell lines, modified at the endogenous level. Thermo Fisher Scientific, in partnership with Horizon Discovery, is offering a large collection of human knockout cell lines, and also provides rapid on-demand cell line generation when the knockout you need isn’t available off the shelf.

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Basics of Detection & Analysis

Understanding the workflow and probing the efficiency and consequences of gene editing are crucial for successful precision genome manipulation. This webinar is designed for researchers just getting started with genome editing, and others who want to learn the essentials of how to design detection and analysis experiments. Listen to this on-demand webinar to learn effective strategies for detection and analysis of genomic modification induced by engineered nucleases.

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Basics of Design: Knockout and Knock-in Design Using TAL Effectors and CRISPRs

Does your work involve disease models? Do you need to introduce specific genomic changes in the cells of your choice? Do you want to knock out or knock in a gene in your model cells? If the answer to any of these questions is yes, this is a must-see webinar. The last few years have seen dramatic technical leaps in the ability to precisely manipulate the mammalian genome. Development of precision genome editing tools like TAL (transcription activator-like) effector nucleases and CRISPR (clustered regularly interspaced palindromic repeat) systems has enabled the specific introduction of targeted DNA double-strand breaks. Cellular machinery primarily repairs these breaks via the nonhomologous end-joining pathway, which can introduce small insertions or deletions at the break site (thereby causing a disruption). Both TAL effectors and CRISPR systems have been used to generate gene disruptions, perform SNP corrections, and direct gene insertions. Learn about common strategies for achieving these goals, including designing the editing tool and donor DNAs using our TAL and CRISPR technologies.

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NEW Editing tool targeting any DNA sequence

Transcription activator-like (TAL) effector proteins provide custom DNA-binding domains for accurate DNA targeting and precise genome editing. A limitation of traditional TAL methods is that they require a 5’ T at the beginning of their binding sequences. Recently, however, a more powerful TAL tool was developed that allows scientists to target any sequence in the genome. GeneArt PerfectMatch TALs leverage this new technology and can be designed to target any locus in the genome. Data and results show efficient cleavage with both RNA and DNA formats.  Join us for this new webinar focused on the latest advancements on TAL technology.

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An introduction to RNA-guided genome editing with CRISPR

Genome editing technique involves the use of engineered nucleases in conjunction with endogenous repair mechanisms to insert, delete, or replace a specific DNA sequence from a desired location in the genome. Recently, the Type II CRISPR/Cas bacterial adaptive immune system from Streptococcus pyogenes has been engineered and demonstrated to function as an effective gene-editing tool in various eukaryotic genomes, including mammalian. This webinar provides an overview on CRISPR/Cas9-mediated genome editing.

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