DNA Methylation Analysis
DNA methylation is a key epigenetic modification to cytosines, often in CpG dinucleotides. This modification has been frequently associated with gene silencing, but the precise role of DNA methylation in development and disease remains a mystery.
We offer advanced solutions for bisulfite-based applications, DNA methylation enrichment, and sequencing that address the challenges involved with studying DNA methylation.
Robust kits for bisulfite conversion and DNA methylation affinity enrichment that are compatible with a variety of downstream analysis techniques ranging from next-generation sequencing to qPCR.
Workflows from focused detection via CE sequencing to genome-wide analysis with next-generation sequencing.
Optimized kits for locus-specific DNA methylation detection including DNA methylation–sensitive HRM, and bisulfite sequencing.
Epigenetics Learning Center
Listen to Dr. Gavin Meredith discuss the advantages of MBD-based DNA methylation affinity enrichment combined with next-generation sequencing.
Access useful tools to facilitate your DNA methylation studies, including:
- Application notes
- Tutorials and user guides