Laser Capture Microdissection System Overview

The Applied Biosystems Arcturus LCM System offers the power of two lasers—combining laser-capture and laser cutting into one system.

In oncology, neuroscience, biology, or even forensics, your sample preparation with laser capture microdissection can set you up for success in your downstream analyses, whether it’s next-generation sequencing, capillary electrophoresis, microarray analysis, qPCR, or real time-PCR.

The best of both worlds—power and precision in one
  • Gentle IR laser ideal for capture of single cells and small numbers of cells
  • UV laser offers superior speed and precision optimal for dense tissue structures and capturing large numbers of cells
  • Simple, intuitive system designed to enable custody of your sample
  • Complete system for microgenomics

Choose from UV and IR lasers for your cutting and capture

  • IR and UV lasers give you flexibility in your preparation, allowing you to use any slide type


Laser capture microdissection applications

Genetic profiling for blood brain barrier diseases—life in real-time

Dr. Joel Pachter, Professor of Cell Biology at the University of Connecticut Health Center, discusses how he was able genetically profile micro-vessels to monitor changes during the progression of inflammatory disease such as multiple sclerosis. Take a look at how Dr. Pachter used the Applied Biosystems laser capture microdissection (LCM)/qPCR workflow to get a better understanding of how to begin to develop pharmacotherapies to address diseases associated with the blood brain barrier.

Sample preparation for pure tumor samples affects results

Dr. Chip Petricoin at the Center for Applied Proteomics and Molecular Medicine at George Mason University discovered, using laser capture  microdissection, that pure tumor samples were affected by the unknown and unknowable amounts of stroma and other cells.

Learn more about neuroscience research with LCM ›

Learn more about oncology research with LCM ›

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