Precise, efficient gene sequence targeting and modification technologies

From precision genome editing and gene modification technologies to high-efficiency delivery systems, we have developed a broad range of solutions to help you create the modified genes, expression systems, and stable cell lines you need for your research—from culturing cells to modification, detection, and analysis. Our technologies—including GeneArt® TALs and CRISPRs—enable you to reliably modify genomic sequences and analyze the phenotypic outcomes. In addition, we can deploy a combination of advanced technologies to produce a custom construct or cell line that meets your specifications. Balancing performance and cost, our cell engineering portfolio is built on 20 years of industry-leading innovation and can grow with your research needs.

Which technology?   Request Genome Editing eBook  

Featured technologies

Precise and flexible editing; targeting to any gene in any cell, with all-around freedom.

Perform siRNA- or miRNA-mediated loss-of-function analysis in eukaryotic systems.

Quickly design optimal CRISPR gRNAs with minimal off-target effects. 

CRISPR Transfection

We have optimized products & protocols to achieve high cleavage efficiency and ease of delivery for CRISPR-Cas9 complexes

Rapid and efficient editing with multiplexing capabilities.

The world's largest collection of ready-to-go CRISPR engineered cell lines.

Essential tools for monitoring the efficiency of your genome editing experiments.

Featured genome editing applications


Tools for plant genome editing, cloning, DNA assembly, amplification, and analysis, plus Agrobacterium tumefaciens LBA4404 for transformation.


Modify and study gene and protein expression, and explore disease and differentiation pathways, using a variety of gene delivery techniques.


We now offer both off-the-shelf engineered cell lines and custom design and engineering services to deliver the cell lines you need with high quality and service.

Featured videos

Genome editing with engineered nucleases

The evolution of genome engineering

Need assistance with CRISPR gRNA design?

Our new CRISPR Search & Design tool allows you to search our database of >600,000 predesigned CRISPR gRNAs in human and mouse genes or analyze your sequence of interest for de novo gRNA designs using our proprietary algorithms. Up to 25 gRNA sequences per gene are provided with recommendations based on potential off-target effects for each CRISPR sequence.

Start designing today

Technical resources

New Genome Editing Support Center

Find tips, troubleshooting help, and resources for your genome editing applications

Cell engineering and genome editing webinars

Further your knowledge by registering for our latest live webinars, or view one of our recorded webinars at your leisure.

Genome editing publications

Gain insight and find in-depth technical information for your experiments with the latest genome editing publications; also see our genome editing poster series.


Downloadable tools

Web resources