Whole Genome Sequencing by Ion Torrent™ Next-Generation Sequencing

Whole genome sequencing is used to read the complete DNA sequence of an organism. It has been applied to a wide range of scientific questions, such as those related to the study of inherited diseases, cancer, infectious diseases, prenatal genetics, and much more. Ion Torrent™ next-generation sequencing is ideal for whole genome sequencing of species of various sizes and complexities.

Microbial Genome Sequencing

The evolution of fast, affordable whole genome sequencing of microbes has been critical for facilitating a rapid response during disease surveillance, for investigating disease outbreaks, and for determining disease etiology. The power of Ion Torrent™ next-generation sequencing can be used to discriminate between closely related strains and to track the evolution of disease-associated isolates in real time, offering the possibility of incredibly fast identification of outbreak strains.

Human-Scale Low-Coverage Genome Aneuploidy Assessment

Researchers focusing on detecting aneuploidy—abnormal chromosome numbers—can use the Ion PGM™ System with whole genome amplification from a single cell and low-pass copy number analysis with Ion Reporter™ Software. This application is faster than microarray or karyotyping analysis and enables multiplexing of samples, offering researchers a flexible and less expensive platform that can deliver accurate data in a single day.

Human-Scale Deep Genome Sequencing

Whole genome sequencing has also been used to uncover the role of de novo mutations in sporadic and inherited diseases, to provide insights into the complexity of cancer, and to identify new genes and biological pathways implicated in tumor initiation, progression, and metastasis. Whole genome sequencing has also provided a glimpse into our planet's genetic past—for example, by uncovering the genome sequences of extinct species such as Neanderthal man and the woolly mammoth. Fast, affordable human-scale genome sequencing using Ion Torrent™ semiconductor technology will help accelerate the application of whole genome sequencing to many additional scientific questions.

Solutions for Whole Genome Sequencing

Whole genome sequencing is the definitive tool for discovering variation.  Recent advances in terms of cost and speed have made whole genome sequencing more affordable and more accessible. Consider the following solutions to begin cost-effective, scalable human-scale genome sequencing studies in your lab: 

  • The Ion Proton™ System will enable human-scale genome sequencing with the Ion PII™ Chip*
  • The Ion Proton™ System will be able to deliver a $1,000 genome in a few hours, with the total process completed in a single day
  • Intuitive and simple data analysis using Ion Reporter™ Software for the annotation of common and rare variants

The Ion Proton™ System, combined with the Ion PII™ Chip, will make human-scale genome sequencing accessible with a benchtop sequencer affordable to most laboratory budgets.


*The content herein may relate to products that have not been officially released and is subject to change without notice.
For Research Use Only. Not for use in diagnostic procedures.