AKAP450 (A-Kinase anchoring protein 450) is a coiled-coil, scaffolding protein. It is a member of a group of AKAP's, derived from a spliced gene located on human choromosome 7. AKAP450 regulates kinases which participate in centrosomal structure and regulation.
AKAP450 also functions as an MR-1 binding protein with potential action in cytoskeletal attachment oof the NMDA receptor. It has also been found to be specifically concentrated at the skelatal muscle and neuromuscular junction.