Antibodies that detect FBXW7 can be used in several scientific applications, including Western Blot, Immunohistochemistry (Paraffin), Immunoprecipitation, Immunohistochemistry and Immunocytochemistry. These antibodies target FBXW7 in Human, Mouse and Rat samples. Our FBXW7 monoclonal and polyclonal antibodies are developed in Mouse and Rabbit. These antibodies have been verified by Relative expression to confirm specificity to FBXW7. Find the FBXW7 antibody that fits your needs. Choose from 1 of 33 FBXW7 antibodies, which have been validated in experiments with 7 publications and 43 images featured in our data gallery.
Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the antibody you re looking for, contact us today to develop custom antibodies for specific targets, species and applications. View more
F-Box and WD Repeat Domain Containing 7 (FBXW7) is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. FBXW7 was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.
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