Antibodies that detect GPAM can be used in several scientific applications, including Western Blot, Immunocytochemistry, Immunohistochemistry, Immunohistochemistry (Paraffin) and Immunohistochemistry (Frozen). These antibodies target GPAM in Human, Rat and Mouse samples. Our GPAM polyclonal antibodies are developed in Rabbit and Mouse. These antibodies have been verified by Cell treatment to confirm specificity to GPAM. Find the GPAM antibody that fits your needs. Choose from 1 of 6 GPAM antibodies, which have been validated in experiments with 15 images featured in our data gallery.
Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the antibody you re looking for, contact us today to develop custom antibodies for specific targets, species and applications. View more
Glycerol-3-phosphate acyltransferase 1 (GPAT1), one of four known GPAT isoforms, is located on the mitochondrial outer membrane, allowing reciprocal regulation with carnitine palmitoyltransferase-1. It is thought to be critical for the development of hepatic steatosis; steatosis triggered by GPAT1 overexpression leads to hepatic and possibly peripheral insulin resistance. GPAT1 is transcriptionally upregulated by insulin and sterol regulatory element binding protein (SREBP-1) and downregulated by AMP-activated protein kinase. Mice deficient in GPAT1 exhibit decreased triacylglycerol (TAG) in cardiomyocytes even in high-fat diets, suggesting that GPAT1 contributes significantly to TAG accumulation in heart tissue during lipogenic or high fat diets. At least two isoforms of GPAT1 are known to exist.
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