Principal Names: ROPN1L; Ropporin-1 like; ASP; AKAP-associated sperm protein; Official Gene Symbol: ROPN1L Gene ID: 83853 (human) Gene Map Locus: 5p15.2 (human) AKAPs act as scaffolding proteinscoordinating phosphatase/kinase signaling at the cytoskeleton. They interact with PKAs and anchor them to specific sub-cellular compartments and participate in multiple cellular processes including growth, metabolism and differentiation. ASP, a 26 kDa protein, is a novel AKAP-interacting protein. It interacts with the amphipathic helix of AKAP3 and facilitates AKAP3-PKA interactions. It consists of a conserved N-terminal AKAP-binding domain and a central cysteine-rich Fz domain. It is specifically expressed in the sperms and might play a significant role in sperm motility and also facilitate cytoskeletal reorganization during spermiogenesis.View more
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