Ribosomes, the organelles that catalyze protein synthesis, are composed of a small subunit (40S) and a large subunit (60S) that consist of over 80 distinct ribosomal proteins. Mammalian ribosomal proteins are encoded by multigene families that contain processed pseudogenes and one functional intron-containing gene within their coding regions. Ribosomal Protein S17, also known as RPS17, RPS17L1 or RPS17L2, is a 135 amino acid protein that is a component of the 40S subunit. Localized to the cytoplasm and expressed ubiquitously, Ribosomal Protein S17 belongs to the S17e family of ribosomal proteins and functions in protein synthesis. Mutations in the gene encoding Ribosomal Protein S17 are associated with Diamond-Blackfan anemia (DBA), a rare congenital disorder characterized by defective differentiation of pro-erythroblasts. Like most ribosomal proteins, Ribosomal Protein S17 exists as multiple processed pseudogenes that are scattered throughout the genome.View more
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