TES maps to a common fragile site on chromosome 7q31.2 designated FRA7G and this gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. Multiple protein isoforms are encoded by transcript variants of the TES gene and Cancer-associated chromosomal changes often involve regions containing fragile sites involving the TES gene.View more View less
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