Antibodies that detect 4-1BBL (CD137L) can be used in several scientific applications, including Flow Cytometry, Western Blot, Immunocytochemistry, ELISA and Immunohistochemistry (Paraffin). These antibodies target 4-1BBL (CD137L) in Human, Mouse and Rat samples. Our 4-1BBL (CD137L) monoclonal, polyclonal and recombinant monoclonal antibodies are developed in Mouse, Rabbit, Rat and Goat. Find the 4-1BBL (CD137L) antibody that fits your needs. Choose from 1 of 22 4-1BBL (CD137L) antibodies, which have been validated in experiments with 7 publications and 29 images featured in our data gallery.
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CD137 ligand (CD137L) is a type II membrane protein and part of the TNF superfamily. CD137L is a co-stimulatory molecule that is expressed on antigen presenting cells (DCs, monocytes/macrophages, B cells) and is upregulated upon activation. Its receptor, CD137/4-1BB, is found on a variety of cells, including inflamed endothelial cells, where its expression enhances extravasation of CD137L expressing monocytes. Activated T cells also express CD137, and engagement with CD137L enhances T cell proliferation, IL-2 secretion, survival, and cytotoxic activity. CD137L is also expressed on a majority of B-cell lymphomas, including mantle cell lymphoma, follicular lymphoma, and diffuse large B-cell lymphoma (but it is lacking on Hodgkin lymphoma and T-cell lymphoma). CD137L is also expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interactions.
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