Adgrb1 is a phosphatidylserine receptor that enhances the engulfment of apoptotic cells, likely to be a potent inhibitor of angiogenesis in brain, and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. Adgrb1 may function in cell adhesion and signal transduction in the brain. Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. As such, tumors obtain blood supply for their growth, are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. Adgrb1 contains at least one functional p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated Adgrb1 and BAI3, which have similar tissue specificities and structures, however only Adgrb1 is transcriptionally regulated by p53. Adgrb1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas. Diseases associated with ADGRB1 include Glioblastoma.
Adhesion G protein-coupled receptor B1; Brain-specific angiogenesis inhibitor 1; Vasculostatin-120; Vasculostatin-40; Vstat-40; Vstat120; Vstat40