The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.
InvitrogenCD130 Monoclonal Antibody (AN-G30), Biotin, eBioscience™ CD130 Monoclonal Antibody (AN-G30), Biotin, eBioscience™
Cat # 13-1308-82
InvitrogenCD130 Monoclonal Antibody (KGP130), PE, eBioscience™ CD130 Monoclonal Antibody (KGP130), PE, eBioscience™
Cat # 12-1302-82
InvitrogenCD130 Monoclonal Antibody (KGP130), APC, eBioscience™ CD130 Monoclonal Antibody (KGP130), APC, eBioscience™
Cat # 17-1302-82
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.