CD21 (complement receptor 2, CR2) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to folicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands.
CD21; Complement C3d receptor; complement component (3d/Epstein Barr virus) receptor 2; Complement receptor type 2; Cr2; EBV receptor; Epstein-Barr virus receptor
Please enter the information below and press OK to send your cart to Core Services for purchase.