Fc receptor homologs (FcRH5), also known as IRTA2 proteins, are transmembrane proteins with sequence homology to classical Fc receptor families. FcRH5 function as activating or inhibitory receptors on discrete B cell populations and are involved in B-cell development and differentiation in peripheral lymphoid organs. FcRH5 expression is deregulated in multiple myeloma and Burkitt lymphoma cell lines with 1q21 abnormalities. FcRH5 may play a critical role for the pathogenesis of B-cell lymphoma.
BXMAS1; CD307; CD307e; Fc receptor homolog 5; Fc receptor-like 5; Fc receptor-like protein 5; FcR-like protein 5; FCRH5; Immune receptor translocation-associated protein 2; immunoglobulin superfamily receptor translocation associated 2 (IRTA2); immunoglobulin superfamily receptor translocation associated 2 IRTA2; IRTA2; PRO820
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