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Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp17 protein, which functions in two different cellular processes: pre-mRNA splicing and cell cycle progression. It suggests that this protein may play a role in cell cycle progression.
1200003H23Rik; Cdc40; cell division cycle 40; cell division cycle 40 homolog; EHB3; EH-binding protein 3; hPRP17; pre-mRNA splicing factor 17; pre-mRNA-processing factor 17; PRP17; PRP17 homolog; PRPF17
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