CDH12 is a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.
BR-cadherin; Brain cadherin; brain-cadherin; Cadherin; cadherin 12, type 2 (N-cadherin 2); cadherin, neural type, 2; Cadherin-12; N-cadherin 2; Neural type cadherin 2; neuronal cadherin 2