CEACAM7 is a CEA-related cell adhesion molecule 7 that belongs to the carcinoembryonic antigen (CEA) family. CEACAM7 encodes a glycosyl phosphatidyl inositol (GPI)-linked glycoprotein which is only found on the apical surface of highly differentiated epithelial cells adult colon and on a small epithelial cell population in pancreatic ducts. CEACAM7 expression is completely lost upon malignant transformation already in hyperplastic polyps and early adenomas as well as in adenocarcinomas of the colon. Like all members of the CEACAM family, it consists of a single N domain, with structural homology to the immunoglobulin variable domains, followed by one immunoglobulin constant-like A domain.
BGP7; Carcinoembryonic antigen CGM2; carcinoembryonic antigen gene family member 2; Carcinoembryonic antigen-related cell adhesion molecule 7