CXCL12 is a stromal cell-derived alpha chemokine member of the intercrine family. This gene product and its receptor CXCR4 can activate lymphocytes and have been implicated in the metastasis of some cancers such as breast cancer. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene.
12-O-tetradecanoylphorbol 13-acetate repressed protein 1; C-X-C motif chemokine 12; chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1); PBSF; Pre-B cell growth-stimulating factor; pre-B-cell growth-stimulating factor; SDF-1; SDF-1 gamma; Stromal cell-derived factor 1; stromal cell-derived factor-1 gamma; Thymic lymphoma cell-stimulating factor; TLSF; TPAR1
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