Dec1, which is also known as Stra13 or Sharp2, is a basic helix-loop-helix (bHLH) transcription factor that has been found to play an important role in circadian system. Dec1 contains one basic helix-loop-helix (bHLH) domain, one Orange domain and is reported to be expressed in Treg cells. It is also reported that Dec1 is required for long-term maintenance of Treg cells after adoptive transfer to suppress effector T cell-mediated inflammation. Dec1 positively regulates CD25 expression in association with Runx 1.
Candidate tumor suppressor CTS9; CTS9; Deleted in esophageal cancer 1