Clathrin-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2). Thus, connecdenns link RAB35 activation with the clathrin machinery.
Connecdenn; Connecdenn 1; DENN domain-containing protein 1A; DENN/MADD domain containing 1A; Protein FAM31A; RP11-230L22.3
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