Deptor interacts with the mammalian target of rapamycin (mTOR), inhibiting kinase activities and ultimately negatively regulating the downstream mTOR pathways. Because of its critical role in signaling, changes in expression levels of Deptor can lead to hyperplasia, apoptosis, and several cancers. Deptor seems to lead to cytokine cascades that are important in endometriosis and the induction of labor. Through mTOR interactions, Deptor is implicated in pathways for cell growth and differentiation, as well as cell-cycle prolongation or termination.
DEP domain containing 6; DEP domain containing mTOR interacting protein; DEP domain containing MTOR-interacting protein; DEP domain-containing mTOR-interacting protein; DEP domain-containing protein 6; DEP.6; DEPDC6; FLJ12428