Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2.
Dolichol-phosphate mannose synthase; Dolichol-phosphate mannosyltransferase; Dolichyl-phosphate beta-D-mannosyltransferase; DPM synthase; Mannose-P-dolichol synthase; MPD synthase; OTTMUSP00000017164; RP23-391M18.1
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