FAM120A (C9orf10) is a member of the constitutive coactivator of PPAR -gamma family and the gene was mapped to chromosome 9q22.31. FAM120A was recently detected within the Pur-alpha-containing mRNA-protein complex in the brain. As a novel RNA-binding protein, FAM120A is a critical component of the oxidative stress-induced survival signaling. It may participate in mRNA transport in the cytoplasm. FAM120A activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. FAM120A protects cells from apoptosis through activation of SRKs in response to oxidative stress. Blocking of the survival signaling mediated by FAM120A, which sensitizes the cancer cells to stress-induced apoptosis, may be a novel therapeutic approach for gastric scirrhous carcinoma cells.
C9orf10, DNAPTP1, DNAPTP5, OSSA; Constitutive coactivator of PPAR-gamma-like protein 1; DNA polymerase-transactivated protein 1; DNA polymerase-transactivated protein 5; family with sequence similarity 120A; oxidative stess-associated Src activator; Oxidative stress-associated Src activator; Protein FAM120A