53BP1 (P53-binding protein 1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, 53BP1 is phosphorylated and localizes to the presumptive sites of damage, specifically, double-strand breaks. 53BP1 may have a role in checkpoint signaling during mitosis, enhances TP53-mediated transcriptional activation, and participates in DNA repair by maintaining genomic stability.
Constitutive coactivator of PPAR-gamma-like protein 1; DNAPTP1; DNAPTP5; family with sequence similarity 120A; oxidative stess-associated Src activator; Oxidative stress-associated Src activator; Protein FAM120A
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