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Serves as a substrate-specific adapter for the CUL3-based ubiquitin-protein E3 ligase complex. Negatively regulates the Wnt signaling pathway via the targeted ubiquitination and subsequent proteolysis of DVL3.
AB030242; down regulated by Ctnnb1, a; down-regulated by CTNNB1 protein A; down-regulated by Ctnnb1, a; DRCTNNB1A; Fam126a; family with sequence similarity 126 member A; family with sequence similarity 126, member A; HCC; HLD5; HYCC1; Hyccin; Protein FAM126A; RGD1562906
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