Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly.
E2-induced gene 5 protein; family with sequence similarity 162, member A; Growth and transformation-dependent protein; HGTD-P; HIF-1 alpha-responsive proapoptotic molecule; Protein FAM162A
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