FAM212A, initially identified as INCA (induced in neural crest by AP-2alpha) in xenopus, is expressed primarily in neural crest cells and their derivatives. FAM212A can associate with the P21-kinase protein PAK4 and this association modulates cytoskeletal dynamics. In mammals, FAM212A is thought to play a role in neural tube closure; a significant fraction of FAM212A-null mice exhibited exencephaly.
family with sequence similarity 212, member A; HInca; INCA; Induced in neural crest by AP2-alpha protein homolog; Inka box actin regulator 1; PAK4-inhibitor INKA1
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