Component of the shielding complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres.
family with sequence similarity 35, member A; Protein FAM35A; RINN1-REV7-interacting novel NHEJ regulator 2; Shield complex subunit 2; Shieldin complex subunit 2
Searching for an antibody we don't offer? We make custom antibodies for specific targets, species and applications.
More than 18,000 custom antibodies created so far.Talk to a specialist now