Members of the F-box protein family, such as FBXW12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains.
F-box and WD-40 domain protein 12; F-box and WD-40 domain-containing protein 12; F-box only protein 35; F-box- and WD40-repeat-containing protein; F-box/WD repeat-containing protein 12
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