FOXH1 is a member of the Forkhead-box (FOX) family of transcription factors and is the human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 plays an important role in mediating TGF-beta/activin signals through its interaction with the SMAD2-SMAD4 complex. It is expressed primarily during early development and localizes in the cytoplasm until it forms a complex with the SMAD proteins at which time it translocates to the nucleus to positively or negatively affect gene expression.
Fast-1; Fast-2; FAST1 transcription factor; Forkhead activin signal transducer 1; Forkhead activin signal transducer 2; forkhead activin signal transducer-1; Forkhead box protein H1; hFAST-1; TGF-beta/activin signal transducer
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