FOXN1 is a 648 amino acid protein belonging to the winged helix/forkhead family It contains 1 fork-head DNA-binding domain and is a transcriptional regulator involved in development. FOXN1 is involved in directing lineage choices of multi-potential progenitor epithelial cells and controls important regulating genes of lympho-epithelial interactions. It modulates keratinocyte differentiation in hair follicles and nail apparatus and its defects lead to T-cell immunodeficiency congenital alopecia, nail dystrophy, macroscopic nudity and an inborn dysgenesis of the thymus.
Forkhead box protein N1; Hepatocyte nuclear factor 3 forkhead homolog 11; HFH-11; HNF-3/forkhead homolog 11; JTK1; Rowett nude; winged helix nude; winged-helix nude; Winged-helix transcription factor nude
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