FUCA2 (Alpha-L-fucosidase) catalyzes the hydrolysis of terminal alpha-L-fucosidase linkages in glycosphingolipids and glycoproteins. At least 2 separate polymorphic alpha-L-fucosidases are recognized in man. The FUCA2 locus regulates the level of alpha-fucosidase in plasma and fibroblasts but not in leukocytes. In fucosidosis, deficiency of alpha-L-fucosidase is found in both plasma and leukocytes.
Alpha-L-fucosidase 2; Alpha-L-fucoside fucohydrolase 2; MGC1314; Plasma alpha-L-fucosidase
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