FUT3 comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This protein is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities.
4-fucosyltransferase; alpha (1,3) fucosyltransferase; Alpha-(1,3)-fucosyltransferase 5; alpha-(1,3/1,4)-fucosyltransferase; Blood group Lewis alpha-4-fucosyltransferase; Fuc-TV; Fucosyltransferase 3; fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group); Fucosyltransferase 5; fucosyltransferase 5 (alpha (1,3) fucosyltransferase); Fucosyltransferase III; Fucosyltransferase V; FucT-III; fucT-V; Galactoside 3(4)-L-fucosyltransferase; Galactoside 3-L-fucosyltransferase; Lewis FT; Lewis Y
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