The protein encoded by this gene catalyzes the reduction of 3-ketodihydrosphingosine to dihydrosphingosine. The putative active site residues of the encoded protein are found on the cytosolic side of the endoplasmic reticulum membrane. A chromosomal rearrangement involving this gene is a cause of follicular lymphoma, also known as type II chronic lymphatic leukemia. The mutation of a conserved residue in the bovine ortholog causes spinal muscular atrophy.
3-dehydrosphinganine reductase; 3-ketodihydrosphingosine reductase; DHSR; follicular lymphoma variant translocation 1; Follicular variant translocation protein 1; FVT-1; FVT1; KDS reductase; member 1; SDR35C1; short chain dehydrogenase/reductase family 35C; Short chain dehydrogenase/reductase family 35C member 1; short chain dehydrogenase/reductase family 35C, member 1