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The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene.
66/67kDa; AA407891; adult folate-binding protein; eIF3 p66; EIF3D; eIF3d {ECO:0000255; eIF3p66; eIF3-p66; EIF3S7; eIF-3-zeta; eIF3-zeta; eIF-3-zeta {ECO:0000255; Eukaryotic translation initiation factor 3 subunit 7; eukaryotic translation initiation factor 3 subunit 7 {ECO:0000255; eukaryotic translation initiation factor 3 subunit D; eukaryotic translation initiation factor 3 subunit D {ECO:0000255; eukaryotic translation initiation factor 3, subunit 7 (zeta); eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67kDa; eukaryotic translation initiation factor 3, subunit D; FBP; Fbp1; folate binding protein; folate binding protein 1; folate receptor 1; folate receptor 1 (adult); folate receptor alpha; Folate receptor, adult; folate-binding protein 1; Folbp1; Folbp-1; FOLR; FOLR1; FR-alpha; HAMAP-Rule:MF_03003}; KB cells FBP; MOv18; Ovarian tumor-associated antigen MOv18; translation initiation factor eIF3 p66; translation initiation factor eIF3 p66 subunit
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