Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis.
cytoplasmic; dead end homolog 1; HisRS; histidine translase; histidine tRNA ligase; histidine tRNA ligase 1; histidine--tRNA ligase; Histidine--tRNA ligase, cytoplasmic; histidine-tRNA ligase; Histidyl-tRNA synthetase; histidyl-tRNA synthetase, cytoplasmic; HRS