HERC6 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).
E3 ISG15--protein ligase Herc6; FLJ20637; HECT domain and RCC1-like domain-containing protein 6; hect domain and RLD 5; hect domain and RLD 6; HECT-type E3 ubiquitin transferase HERC6; potential ubiquitin ligase; Probable E3 ubiquitin-protein ligase HERC6
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